Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
p53 gain of function mutants (mutp53) are involved in the pathogenesis of most human cancers. Here, the authors show that mutp53 regulates the tumor microenvironment by inducing the release of specific exosomes containing miR-1246 that once received by macrophages turns them into tumor supportive ma...
Guardado en:
Autores principales: | Tomer Cooks, Ioannis S. Pateras, Lisa M. Jenkins, Keval M. Patel, Ana I. Robles, James Morris, Tim Forshew, Ettore Appella, Vassilis G. Gorgoulis, Curtis C. Harris |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/c7c38fedb00642b095bd023227041cc0 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Editorial: Reprogramming Stromal Cells in Chronic Inflammation and Cancer
por: Ana Igea, et al.
Publicado: (2021) -
Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage
por: Evi Goulielmaki, et al.
Publicado: (2020) -
Acta N°1246
por: Banco Central de Chile
Publicado: (2021) -
Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO
por: Khosrow Kashfi, et al.
Publicado: (2021) -
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
por: David Novo, et al.
Publicado: (2018)