Behavioral abnormalities observed in Zfhx2-deficient mice.

Zfhx2 (also known as zfh-5) encodes a transcription factor containing three homeobox domains and 18 Zn-finger motifs. We have reported that Zfhx2 mRNA is expressed mainly in differentiating neurons in the mouse brain and its expression level is negatively regulated by the antisense transcripts of Zf...

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Autores principales:	Yuriko Komine, Keizo Takao, Tsuyoshi Miyakawa, Tetsuo Yamamori
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7c59388361e49b7a8b1a77df2c7955d
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spelling	oai:doaj.org-article:c7c59388361e49b7a8b1a77df2c7955d2021-11-18T08:03:03ZBehavioral abnormalities observed in Zfhx2-deficient mice.1932-620310.1371/journal.pone.0053114https://doaj.org/article/c7c59388361e49b7a8b1a77df2c7955d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300874/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Zfhx2 (also known as zfh-5) encodes a transcription factor containing three homeobox domains and 18 Zn-finger motifs. We have reported that Zfhx2 mRNA is expressed mainly in differentiating neurons in the mouse brain and its expression level is negatively regulated by the antisense transcripts of Zfhx2. Although the expression profile of Zfhx2 suggests that ZFHX2 might have a role in a particular step of neuronal differentiation, the specific function of the gene has not been determined. We generated a Zfhx2-deficient mouse line and performed a comprehensive battery of behavioral tests to elucidate the function of ZFHX2. Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype. These behavioral phenotypes suggest that ZFHX2 might play roles in controlling emotional aspects through the function of monoaminergic neurons where ZFHX2 is expressed. Moreover, considering their phenotypes, the Zfhx2-deficient mice may provide a novel model of human psychiatric disorders.Yuriko KomineKeizo TakaoTsuyoshi MiyakawaTetsuo YamamoriPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e53114 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuriko Komine Keizo Takao Tsuyoshi Miyakawa Tetsuo Yamamori Behavioral abnormalities observed in Zfhx2-deficient mice.
description	Zfhx2 (also known as zfh-5) encodes a transcription factor containing three homeobox domains and 18 Zn-finger motifs. We have reported that Zfhx2 mRNA is expressed mainly in differentiating neurons in the mouse brain and its expression level is negatively regulated by the antisense transcripts of Zfhx2. Although the expression profile of Zfhx2 suggests that ZFHX2 might have a role in a particular step of neuronal differentiation, the specific function of the gene has not been determined. We generated a Zfhx2-deficient mouse line and performed a comprehensive battery of behavioral tests to elucidate the function of ZFHX2. Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype. These behavioral phenotypes suggest that ZFHX2 might play roles in controlling emotional aspects through the function of monoaminergic neurons where ZFHX2 is expressed. Moreover, considering their phenotypes, the Zfhx2-deficient mice may provide a novel model of human psychiatric disorders.
format	article
author	Yuriko Komine Keizo Takao Tsuyoshi Miyakawa Tetsuo Yamamori
author_facet	Yuriko Komine Keizo Takao Tsuyoshi Miyakawa Tetsuo Yamamori
author_sort	Yuriko Komine
title	Behavioral abnormalities observed in Zfhx2-deficient mice.
title_short	Behavioral abnormalities observed in Zfhx2-deficient mice.
title_full	Behavioral abnormalities observed in Zfhx2-deficient mice.
title_fullStr	Behavioral abnormalities observed in Zfhx2-deficient mice.
title_full_unstemmed	Behavioral abnormalities observed in Zfhx2-deficient mice.
title_sort	behavioral abnormalities observed in zfhx2-deficient mice.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c7c59388361e49b7a8b1a77df2c7955d
work_keys_str_mv	AT yurikokomine behavioralabnormalitiesobservedinzfhx2deficientmice AT keizotakao behavioralabnormalitiesobservedinzfhx2deficientmice AT tsuyoshimiyakawa behavioralabnormalitiesobservedinzfhx2deficientmice AT tetsuoyamamori behavioralabnormalitiesobservedinzfhx2deficientmice
_version_	1718422632695595008

Behavioral abnormalities observed in Zfhx2-deficient mice.

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