Genomic characterization of rare molecular subclasses of hepatocellular carcinoma

Jeffrey Damrauer, Markia Smith et al. used existing datasets from cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) to characterize two subsets of HCC distinct from prototypical HCC tumors, based on comprehensive analysis of molecular data. The two classes differed from HCC by their copy n...

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Autores principales:	Jeffrey S. Damrauer, Markia A. Smith, Vonn Walter, Aatish Thennavan, Lisle E. Mose, Sara R. Selitsky, Katherine A. Hoadley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c7c5f92165e344fcb51842120c0bf9d1
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spelling	oai:doaj.org-article:c7c5f92165e344fcb51842120c0bf9d12021-12-02T19:16:17ZGenomic characterization of rare molecular subclasses of hepatocellular carcinoma10.1038/s42003-021-02674-12399-3642https://doaj.org/article/c7c5f92165e344fcb51842120c0bf9d12021-10-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02674-1https://doaj.org/toc/2399-3642Jeffrey Damrauer, Markia Smith et al. used existing datasets from cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) to characterize two subsets of HCC distinct from prototypical HCC tumors, based on comprehensive analysis of molecular data. The two classes differed from HCC by their copy number, gene expression and mutational signature and exhibited worse progression free survival, highlighting the need to identify class-specific biomarkers and develop targeted therapies for these forms of cancer.Jeffrey S. DamrauerMarkia A. SmithVonn WalterAatish ThennavanLisle E. MoseSara R. SelitskyKatherine A. HoadleyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jeffrey S. Damrauer Markia A. Smith Vonn Walter Aatish Thennavan Lisle E. Mose Sara R. Selitsky Katherine A. Hoadley Genomic characterization of rare molecular subclasses of hepatocellular carcinoma
description	Jeffrey Damrauer, Markia Smith et al. used existing datasets from cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) to characterize two subsets of HCC distinct from prototypical HCC tumors, based on comprehensive analysis of molecular data. The two classes differed from HCC by their copy number, gene expression and mutational signature and exhibited worse progression free survival, highlighting the need to identify class-specific biomarkers and develop targeted therapies for these forms of cancer.
format	article
author	Jeffrey S. Damrauer Markia A. Smith Vonn Walter Aatish Thennavan Lisle E. Mose Sara R. Selitsky Katherine A. Hoadley
author_facet	Jeffrey S. Damrauer Markia A. Smith Vonn Walter Aatish Thennavan Lisle E. Mose Sara R. Selitsky Katherine A. Hoadley
author_sort	Jeffrey S. Damrauer
title	Genomic characterization of rare molecular subclasses of hepatocellular carcinoma
title_short	Genomic characterization of rare molecular subclasses of hepatocellular carcinoma
title_full	Genomic characterization of rare molecular subclasses of hepatocellular carcinoma
title_fullStr	Genomic characterization of rare molecular subclasses of hepatocellular carcinoma
title_full_unstemmed	Genomic characterization of rare molecular subclasses of hepatocellular carcinoma
title_sort	genomic characterization of rare molecular subclasses of hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c7c5f92165e344fcb51842120c0bf9d1
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Genomic characterization of rare molecular subclasses of hepatocellular carcinoma

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