Smart material based on boron crosslinked polymers with potential applications in cancer radiation therapy

Abstract Organoboron compounds have been playing an increasingly important role in analytical chemistry, material science, health applications, and particularly as functional polymers like boron carriers for cancer therapy. There are two main applications of boron isotopes in radiation cancer therap...

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Autores principales:	José Vedelago, Facundo Mattea, Sebastián Triviño, María del Mar Montesinos, Walter Keil, Mauro Valente, Marcelo Romero
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7c9cf32537c402fb9172d1dea0a89fe
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spelling	oai:doaj.org-article:c7c9cf32537c402fb9172d1dea0a89fe2021-12-02T17:52:12ZSmart material based on boron crosslinked polymers with potential applications in cancer radiation therapy10.1038/s41598-021-91413-x2045-2322https://doaj.org/article/c7c9cf32537c402fb9172d1dea0a89fe2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91413-xhttps://doaj.org/toc/2045-2322Abstract Organoboron compounds have been playing an increasingly important role in analytical chemistry, material science, health applications, and particularly as functional polymers like boron carriers for cancer therapy. There are two main applications of boron isotopes in radiation cancer therapy, Boron Neutron Capture Therapy and Proton Boron Fusion Therapy. In this study, a novel and original material consisting of a three-dimensional polymer network crosslinked with $$^{10}$$ 10 B enriched boric acid molecules is proposed and synthesized. The effects of the exposition to thermal neutrons were studied analyzing changes in the mechanical properties of the proposed material. Dedicated Monte Carlo simulations, based on MCNP and FLUKA main codes, were performed to characterize interactions of the proposed material with neutrons, photons, and charged particles typically present in mixed fields in nuclear reactor irradiations. Experimental results and Monte Carlo simulations were in agreement, thus justifying further studies of this promising material.José VedelagoFacundo MatteaSebastián TriviñoMaría del Mar MontesinosWalter KeilMauro ValenteMarcelo RomeroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q José Vedelago Facundo Mattea Sebastián Triviño María del Mar Montesinos Walter Keil Mauro Valente Marcelo Romero Smart material based on boron crosslinked polymers with potential applications in cancer radiation therapy
description	Abstract Organoboron compounds have been playing an increasingly important role in analytical chemistry, material science, health applications, and particularly as functional polymers like boron carriers for cancer therapy. There are two main applications of boron isotopes in radiation cancer therapy, Boron Neutron Capture Therapy and Proton Boron Fusion Therapy. In this study, a novel and original material consisting of a three-dimensional polymer network crosslinked with $$^{10}$$ 10 B enriched boric acid molecules is proposed and synthesized. The effects of the exposition to thermal neutrons were studied analyzing changes in the mechanical properties of the proposed material. Dedicated Monte Carlo simulations, based on MCNP and FLUKA main codes, were performed to characterize interactions of the proposed material with neutrons, photons, and charged particles typically present in mixed fields in nuclear reactor irradiations. Experimental results and Monte Carlo simulations were in agreement, thus justifying further studies of this promising material.
format	article
author	José Vedelago Facundo Mattea Sebastián Triviño María del Mar Montesinos Walter Keil Mauro Valente Marcelo Romero
author_facet	José Vedelago Facundo Mattea Sebastián Triviño María del Mar Montesinos Walter Keil Mauro Valente Marcelo Romero
author_sort	José Vedelago
title	Smart material based on boron crosslinked polymers with potential applications in cancer radiation therapy
title_short	Smart material based on boron crosslinked polymers with potential applications in cancer radiation therapy
title_full	Smart material based on boron crosslinked polymers with potential applications in cancer radiation therapy
title_fullStr	Smart material based on boron crosslinked polymers with potential applications in cancer radiation therapy
title_full_unstemmed	Smart material based on boron crosslinked polymers with potential applications in cancer radiation therapy
title_sort	smart material based on boron crosslinked polymers with potential applications in cancer radiation therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c7c9cf32537c402fb9172d1dea0a89fe
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Smart material based on boron crosslinked polymers with potential applications in cancer radiation therapy

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