KINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE

The activation energy variation can be used as a quick measure to differentiate polymorphs of active pharmaceutical ingredients. In this paper diverse phenytoin crystal habits have been obtained through processes of recrystallization in different solvents. Some of these solids differ in melting poi...

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Auteurs principaux:	Oscar A. FLOREZ A., Gloria E. TOBÓN Z., Erika M. LOPERA G.
Format:	article
Langue:	EN
Publié:	Universidad de Antioquia 2009
Sujets:	pseudopolymorphs activation energy recrystallization. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Accès en ligne:	https://doaj.org/article/c7cae86dd57e4933a968831709806e23
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id	oai:doaj.org-article:c7cae86dd57e4933a968831709806e23
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spelling	oai:doaj.org-article:c7cae86dd57e4933a968831709806e232021-11-19T04:14:52ZKINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE0121-40042145-2660https://doaj.org/article/c7cae86dd57e4933a968831709806e232009-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/2805https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 The activation energy variation can be used as a quick measure to differentiate polymorphs of active pharmaceutical ingredients. In this paper diverse phenytoin crystal habits have been obtained through processes of recrystallization in different solvents. Some of these solids differ in melting point by DSC, but are similar in XRD and FT-IR. From the results of melting point, 4 solids are selected by presenting the most dissimilar values. Their activation energy (Ea) is determined by DSC technique, using 3 theoretical isoconversional nonisothermal models and it is found even that 23 Kcal/ mol of difference separate the most extreme values. Oscar A. FLOREZ A.Gloria E. TOBÓN Z.Erika M. LOPERA G.Universidad de Antioquiaarticlepseudopolymorphsactivation energyrecrystallization.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 16, Iss 3 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	pseudopolymorphs activation energy recrystallization. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	pseudopolymorphs activation energy recrystallization. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Oscar A. FLOREZ A. Gloria E. TOBÓN Z. Erika M. LOPERA G. KINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE
description	The activation energy variation can be used as a quick measure to differentiate polymorphs of active pharmaceutical ingredients. In this paper diverse phenytoin crystal habits have been obtained through processes of recrystallization in different solvents. Some of these solids differ in melting point by DSC, but are similar in XRD and FT-IR. From the results of melting point, 4 solids are selected by presenting the most dissimilar values. Their activation energy (Ea) is determined by DSC technique, using 3 theoretical isoconversional nonisothermal models and it is found even that 23 Kcal/ mol of difference separate the most extreme values.
format	article
author	Oscar A. FLOREZ A. Gloria E. TOBÓN Z. Erika M. LOPERA G.
author_facet	Oscar A. FLOREZ A. Gloria E. TOBÓN Z. Erika M. LOPERA G.
author_sort	Oscar A. FLOREZ A.
title	KINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE
title_short	KINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE
title_full	KINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE
title_fullStr	KINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE
title_full_unstemmed	KINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE
title_sort	kinetic characterization of different phenytoin polymorphs by dsc technique
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/c7cae86dd57e4933a968831709806e23
work_keys_str_mv	AT oscarafloreza kineticcharacterizationofdifferentphenytoinpolymorphsbydsctechnique AT gloriaetobonz kineticcharacterizationofdifferentphenytoinpolymorphsbydsctechnique AT erikamloperag kineticcharacterizationofdifferentphenytoinpolymorphsbydsctechnique
_version_	1718420467791953920

KINETIC CHARACTERIZATION OF DIFFERENT PHENYTOIN POLYMORPHS BY DSC TECHNIQUE

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