The Effect of Physical Exercise on Cognitive Impairment in Neurodegenerative Disease: From Pathophysiology to Clinical and Rehabilitative Aspects
Neurodegenerative diseases are a group of pathologies that cause severe disability due to motor and cognitive limitations. In particular, cognitive impairment is a growing health and socioeconomic problem which is still difficult to deal with today. As there are no pharmacologically effective treatm...
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2021
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oai:doaj.org-article:c7cc1b3642f349fd973d9289f636cb172021-11-11T17:06:30ZThe Effect of Physical Exercise on Cognitive Impairment in Neurodegenerative Disease: From Pathophysiology to Clinical and Rehabilitative Aspects10.3390/ijms2221116321422-00671661-6596https://doaj.org/article/c7cc1b3642f349fd973d9289f636cb172021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11632https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Neurodegenerative diseases are a group of pathologies that cause severe disability due to motor and cognitive limitations. In particular, cognitive impairment is a growing health and socioeconomic problem which is still difficult to deal with today. As there are no pharmacologically effective treatments for cognitive deficits, scientific interest is growing regarding the possible impacts of healthy lifestyles on them. In this context, physical activity is gaining more and more evidence as a primary prevention intervention, a nonpharmacological therapy and a rehabilitation tool for improving cognitive functions in neurodegenerative diseases. In this descriptive overview we highlight the neurobiological effects of physical exercise, which is able to promote neuroplasticity and neuroprotection by acting at the cytokine and hormonal level, and the consequent positive clinical effects on patients suffering from cognitive impairment.Giacomo FarìPaola LunettiGiovanni PignatelliMaria Vittoria RaeleAlessandra CeraGiulia MintroneMaurizio RanieriMarisa MegnaLoredana CapobiancoMDPI AGarticlephysical activityexerciserehabilitationAlzheimer’s diseaseParkinson’s diseaseBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11632, p 11632 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
physical activity exercise rehabilitation Alzheimer’s disease Parkinson’s disease Biology (General) QH301-705.5 Chemistry QD1-999 |
| spellingShingle |
physical activity exercise rehabilitation Alzheimer’s disease Parkinson’s disease Biology (General) QH301-705.5 Chemistry QD1-999 Giacomo Farì Paola Lunetti Giovanni Pignatelli Maria Vittoria Raele Alessandra Cera Giulia Mintrone Maurizio Ranieri Marisa Megna Loredana Capobianco The Effect of Physical Exercise on Cognitive Impairment in Neurodegenerative Disease: From Pathophysiology to Clinical and Rehabilitative Aspects |
| description |
Neurodegenerative diseases are a group of pathologies that cause severe disability due to motor and cognitive limitations. In particular, cognitive impairment is a growing health and socioeconomic problem which is still difficult to deal with today. As there are no pharmacologically effective treatments for cognitive deficits, scientific interest is growing regarding the possible impacts of healthy lifestyles on them. In this context, physical activity is gaining more and more evidence as a primary prevention intervention, a nonpharmacological therapy and a rehabilitation tool for improving cognitive functions in neurodegenerative diseases. In this descriptive overview we highlight the neurobiological effects of physical exercise, which is able to promote neuroplasticity and neuroprotection by acting at the cytokine and hormonal level, and the consequent positive clinical effects on patients suffering from cognitive impairment. |
| format |
article |
| author |
Giacomo Farì Paola Lunetti Giovanni Pignatelli Maria Vittoria Raele Alessandra Cera Giulia Mintrone Maurizio Ranieri Marisa Megna Loredana Capobianco |
| author_facet |
Giacomo Farì Paola Lunetti Giovanni Pignatelli Maria Vittoria Raele Alessandra Cera Giulia Mintrone Maurizio Ranieri Marisa Megna Loredana Capobianco |
| author_sort |
Giacomo Farì |
| title |
The Effect of Physical Exercise on Cognitive Impairment in Neurodegenerative Disease: From Pathophysiology to Clinical and Rehabilitative Aspects |
| title_short |
The Effect of Physical Exercise on Cognitive Impairment in Neurodegenerative Disease: From Pathophysiology to Clinical and Rehabilitative Aspects |
| title_full |
The Effect of Physical Exercise on Cognitive Impairment in Neurodegenerative Disease: From Pathophysiology to Clinical and Rehabilitative Aspects |
| title_fullStr |
The Effect of Physical Exercise on Cognitive Impairment in Neurodegenerative Disease: From Pathophysiology to Clinical and Rehabilitative Aspects |
| title_full_unstemmed |
The Effect of Physical Exercise on Cognitive Impairment in Neurodegenerative Disease: From Pathophysiology to Clinical and Rehabilitative Aspects |
| title_sort |
effect of physical exercise on cognitive impairment in neurodegenerative disease: from pathophysiology to clinical and rehabilitative aspects |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/c7cc1b3642f349fd973d9289f636cb17 |
| work_keys_str_mv |
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