Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection

Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection

ABSTRACT Human noroviruses (HuNoVs) are the leading cause of nonbacterial gastroenteritis worldwide. Histo-blood group antigen (HBGA) expression is an important susceptibility factor for HuNoV infection based on controlled human infection models and epidemiologic studies that show an association of...

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Main Authors: Kei Haga, Khalil Ettayebi, Victoria R. Tenge, Umesh C. Karandikar, Miranda A. Lewis, Shih-Ching Lin, Frederick H. Neill, B. Vijayalakshmi Ayyar, Xi-Lei Zeng, Göran Larson, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
fucosyltransferase 2
glycobiology
histo-blood group antigens
isogenic enteroids
isogenic organoids
noroviruses
Microbiology
QR1-502
Online Access:https://doaj.org/article/c7d23fae05e64407a2dfc2249cda3572
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https://doaj.org/article/c7d23fae05e64407a2dfc2249cda3572

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