Dynamics of cell-fate determination and patterning in the vascular bundles of Arabidopsis thaliana.

Plant vascular meristems are sets of pluripotent cells that enable radial growth by giving rise to vascular tissues and are therefore crucial to plant development. However, the overall dynamics of cellular determination and patterning in and around vascular meristems is still unexplored. We study th...

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Autores principales:	Mariana Benítez, Jan Hejátko
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7d66a24741f4551b44339721697ccb1
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spelling	oai:doaj.org-article:c7d66a24741f4551b44339721697ccb12021-11-18T07:44:16ZDynamics of cell-fate determination and patterning in the vascular bundles of Arabidopsis thaliana.1932-620310.1371/journal.pone.0063108https://doaj.org/article/c7d66a24741f4551b44339721697ccb12013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23723973/?tool=EBIhttps://doaj.org/toc/1932-6203Plant vascular meristems are sets of pluripotent cells that enable radial growth by giving rise to vascular tissues and are therefore crucial to plant development. However, the overall dynamics of cellular determination and patterning in and around vascular meristems is still unexplored. We study this process in the shoot vascular tissue of Arabidopsis thaliana, which is organized in vascular bundles that contain three basic cell types (procambium, xylem and phloem). A set of molecules involved in this process has now been identified and partially characterized, but it is not yet clear how the regulatory interactions among them, in conjunction with cellular communication processes, give rise to the steady patterns that accompany cell-fate determination and arrangement within vascular bundles. We put forward a dynamic model factoring in the interactions between molecules (genes, peptides, mRNA and hormones) that have been reported to be central in this process, as well as the relevant communication mechanisms. When a few proposed interactions (unverified, but based on related data) are postulated, the model reproduces the hormonal and molecular patterns expected for the three regions within vascular bundles. In order to test the model, we simulated mutant and hormone-depleted systems and compared the results with experimentally reported phenotypes. The proposed model provides a formal framework integrating a set of growing experimental data and renders a dynamic account of how the collective action of hormones, genes, and other molecules may result in the specification of the three main cell types within shoot vascular bundles. It also offers a tool to test the necessity and sufficiency of particular interactions and conditions for vascular patterning and yields novel predictions that may be experimentally tested. Finally, this model provides a reference for further studies comparing the overall dynamics of tissue organization and formation by meristems in other plant organs and species.Mariana BenítezJan HejátkoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63108 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mariana Benítez Jan Hejátko Dynamics of cell-fate determination and patterning in the vascular bundles of Arabidopsis thaliana.
description	Plant vascular meristems are sets of pluripotent cells that enable radial growth by giving rise to vascular tissues and are therefore crucial to plant development. However, the overall dynamics of cellular determination and patterning in and around vascular meristems is still unexplored. We study this process in the shoot vascular tissue of Arabidopsis thaliana, which is organized in vascular bundles that contain three basic cell types (procambium, xylem and phloem). A set of molecules involved in this process has now been identified and partially characterized, but it is not yet clear how the regulatory interactions among them, in conjunction with cellular communication processes, give rise to the steady patterns that accompany cell-fate determination and arrangement within vascular bundles. We put forward a dynamic model factoring in the interactions between molecules (genes, peptides, mRNA and hormones) that have been reported to be central in this process, as well as the relevant communication mechanisms. When a few proposed interactions (unverified, but based on related data) are postulated, the model reproduces the hormonal and molecular patterns expected for the three regions within vascular bundles. In order to test the model, we simulated mutant and hormone-depleted systems and compared the results with experimentally reported phenotypes. The proposed model provides a formal framework integrating a set of growing experimental data and renders a dynamic account of how the collective action of hormones, genes, and other molecules may result in the specification of the three main cell types within shoot vascular bundles. It also offers a tool to test the necessity and sufficiency of particular interactions and conditions for vascular patterning and yields novel predictions that may be experimentally tested. Finally, this model provides a reference for further studies comparing the overall dynamics of tissue organization and formation by meristems in other plant organs and species.
format	article
author	Mariana Benítez Jan Hejátko
author_facet	Mariana Benítez Jan Hejátko
author_sort	Mariana Benítez
title	Dynamics of cell-fate determination and patterning in the vascular bundles of Arabidopsis thaliana.
title_short	Dynamics of cell-fate determination and patterning in the vascular bundles of Arabidopsis thaliana.
title_full	Dynamics of cell-fate determination and patterning in the vascular bundles of Arabidopsis thaliana.
title_fullStr	Dynamics of cell-fate determination and patterning in the vascular bundles of Arabidopsis thaliana.
title_full_unstemmed	Dynamics of cell-fate determination and patterning in the vascular bundles of Arabidopsis thaliana.
title_sort	dynamics of cell-fate determination and patterning in the vascular bundles of arabidopsis thaliana.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c7d66a24741f4551b44339721697ccb1
work_keys_str_mv	AT marianabenitez dynamicsofcellfatedeterminationandpatterninginthevascularbundlesofarabidopsisthaliana AT janhejatko dynamicsofcellfatedeterminationandpatterninginthevascularbundlesofarabidopsisthaliana
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Dynamics of cell-fate determination and patterning in the vascular bundles of Arabidopsis thaliana.

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