Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques.
Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report...
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Public Library of Science (PLoS)
2017
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oai:doaj.org-article:c7d96184abee40dd90777c869ba3f5142021-12-02T19:59:39ZHighly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques.1553-73661553-737410.1371/journal.ppat.1006378https://doaj.org/article/c7d96184abee40dd90777c869ba3f5142017-05-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1006378https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated.Sydney M NguyenKathleen M AntonyDawn M DudleySarah KohnHeather A SimmonsBryce WolfeM Shahriar SalamatLeandro B C TeixeiraGregory J WiepzTroy H ThoongMatthew T AliotaAndrea M WeilerGabrielle L BarryKim L WeisgrauLogan J VoslerMariel S MohnsMeghan E BreitbachLaurel M StewartMustafa N RasheedChristina M NewmanMichael E GrahamOliver E WiebenPatrick A TurskiKevin M JohnsonJennifer PostJennifer M HayesNancy Schultz-DarkenMichele L SchotzkoJosh A EudaileySallie R PermarEva G RakaszEmma L MohrSaverio CapuanoAlice F TarantalJorge E OsorioShelby L O'ConnorThomas C FriedrichDavid H O'ConnorThaddeus G GolosPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 13, Iss 5, p e1006378 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Sydney M Nguyen Kathleen M Antony Dawn M Dudley Sarah Kohn Heather A Simmons Bryce Wolfe M Shahriar Salamat Leandro B C Teixeira Gregory J Wiepz Troy H Thoong Matthew T Aliota Andrea M Weiler Gabrielle L Barry Kim L Weisgrau Logan J Vosler Mariel S Mohns Meghan E Breitbach Laurel M Stewart Mustafa N Rasheed Christina M Newman Michael E Graham Oliver E Wieben Patrick A Turski Kevin M Johnson Jennifer Post Jennifer M Hayes Nancy Schultz-Darken Michele L Schotzko Josh A Eudailey Sallie R Permar Eva G Rakasz Emma L Mohr Saverio Capuano Alice F Tarantal Jorge E Osorio Shelby L O'Connor Thomas C Friedrich David H O'Connor Thaddeus G Golos Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques. |
| description |
Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated. |
| format |
article |
| author |
Sydney M Nguyen Kathleen M Antony Dawn M Dudley Sarah Kohn Heather A Simmons Bryce Wolfe M Shahriar Salamat Leandro B C Teixeira Gregory J Wiepz Troy H Thoong Matthew T Aliota Andrea M Weiler Gabrielle L Barry Kim L Weisgrau Logan J Vosler Mariel S Mohns Meghan E Breitbach Laurel M Stewart Mustafa N Rasheed Christina M Newman Michael E Graham Oliver E Wieben Patrick A Turski Kevin M Johnson Jennifer Post Jennifer M Hayes Nancy Schultz-Darken Michele L Schotzko Josh A Eudailey Sallie R Permar Eva G Rakasz Emma L Mohr Saverio Capuano Alice F Tarantal Jorge E Osorio Shelby L O'Connor Thomas C Friedrich David H O'Connor Thaddeus G Golos |
| author_facet |
Sydney M Nguyen Kathleen M Antony Dawn M Dudley Sarah Kohn Heather A Simmons Bryce Wolfe M Shahriar Salamat Leandro B C Teixeira Gregory J Wiepz Troy H Thoong Matthew T Aliota Andrea M Weiler Gabrielle L Barry Kim L Weisgrau Logan J Vosler Mariel S Mohns Meghan E Breitbach Laurel M Stewart Mustafa N Rasheed Christina M Newman Michael E Graham Oliver E Wieben Patrick A Turski Kevin M Johnson Jennifer Post Jennifer M Hayes Nancy Schultz-Darken Michele L Schotzko Josh A Eudailey Sallie R Permar Eva G Rakasz Emma L Mohr Saverio Capuano Alice F Tarantal Jorge E Osorio Shelby L O'Connor Thomas C Friedrich David H O'Connor Thaddeus G Golos |
| author_sort |
Sydney M Nguyen |
| title |
Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques. |
| title_short |
Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques. |
| title_full |
Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques. |
| title_fullStr |
Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques. |
| title_full_unstemmed |
Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques. |
| title_sort |
highly efficient maternal-fetal zika virus transmission in pregnant rhesus macaques. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2017 |
| url |
https://doaj.org/article/c7d96184abee40dd90777c869ba3f514 |
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