Primary breast lymphoma of childhood: a case report and review of literature

Abstract Background Primary breast lymphoma (PBL) is an extremely rare neoplasm in children; by definition, it manifests in the breast without evidence of lymphoma elsewhere, except ipsilateral axillary nodes. Case presentation We report a case of a 15-year-old girl diagnosed with diffuse large B-ce...

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Autores principales:	Giulia A. Restivo, Marta Pillon, Lara Mussolin, Clara Mosa, Angela Guarina, Angela Trizzino, Salvatore Ialuna, Elisa Carraro, Emanuele S.G. D’Amore, Giovanna Russo, Caterina Elia, Maurizio Mascarin, Adriana Zangara, Paolo D’Angelo, Piero Farruggia
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Primary breast lymphoma rituximab Children Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/c7daf17de31e41b3869e8fb6fbade631
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spelling	oai:doaj.org-article:c7daf17de31e41b3869e8fb6fbade6312021-12-05T12:21:06ZPrimary breast lymphoma of childhood: a case report and review of literature10.1186/s12887-021-03002-61471-2431https://doaj.org/article/c7daf17de31e41b3869e8fb6fbade6312021-11-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-03002-6https://doaj.org/toc/1471-2431Abstract Background Primary breast lymphoma (PBL) is an extremely rare neoplasm in children; by definition, it manifests in the breast without evidence of lymphoma elsewhere, except ipsilateral axillary nodes. Case presentation We report a case of a 15-year-old girl diagnosed with diffuse large B-cell lymphoma (DLBCL) of the right breast: the patient received chemotherapy and rituximab, achieving complete remission. A literature review revealed other 11 cases of pediatric PBL; it mainly affects female adolescents and can involve right and left breast equally. Different histologic subtypes have been described, arising from both B-cell and T-cell. Therapeutic approaches were very different, from chemotherapy to local treatment with surgery and/or radiotherapy. Conclusions Our case is the first in which rituximab was administered, suggesting to be a promising therapy in B-cell PBL, as already demonstrated in pediatric B-cell lymphoma from other sites. Further investigations are needed to identify prognostic factors and establish the most effective treatment.Giulia A. RestivoMarta PillonLara MussolinClara MosaAngela GuarinaAngela TrizzinoSalvatore IalunaElisa CarraroEmanuele S.G. D’AmoreGiovanna RussoCaterina EliaMaurizio MascarinAdriana ZangaraPaolo D’AngeloPiero FarruggiaBMCarticlePrimary breast lymphomarituximabChildrenPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Primary breast lymphoma rituximab Children Pediatrics RJ1-570
spellingShingle	Primary breast lymphoma rituximab Children Pediatrics RJ1-570 Giulia A. Restivo Marta Pillon Lara Mussolin Clara Mosa Angela Guarina Angela Trizzino Salvatore Ialuna Elisa Carraro Emanuele S.G. D’Amore Giovanna Russo Caterina Elia Maurizio Mascarin Adriana Zangara Paolo D’Angelo Piero Farruggia Primary breast lymphoma of childhood: a case report and review of literature
description	Abstract Background Primary breast lymphoma (PBL) is an extremely rare neoplasm in children; by definition, it manifests in the breast without evidence of lymphoma elsewhere, except ipsilateral axillary nodes. Case presentation We report a case of a 15-year-old girl diagnosed with diffuse large B-cell lymphoma (DLBCL) of the right breast: the patient received chemotherapy and rituximab, achieving complete remission. A literature review revealed other 11 cases of pediatric PBL; it mainly affects female adolescents and can involve right and left breast equally. Different histologic subtypes have been described, arising from both B-cell and T-cell. Therapeutic approaches were very different, from chemotherapy to local treatment with surgery and/or radiotherapy. Conclusions Our case is the first in which rituximab was administered, suggesting to be a promising therapy in B-cell PBL, as already demonstrated in pediatric B-cell lymphoma from other sites. Further investigations are needed to identify prognostic factors and establish the most effective treatment.
format	article
author	Giulia A. Restivo Marta Pillon Lara Mussolin Clara Mosa Angela Guarina Angela Trizzino Salvatore Ialuna Elisa Carraro Emanuele S.G. D’Amore Giovanna Russo Caterina Elia Maurizio Mascarin Adriana Zangara Paolo D’Angelo Piero Farruggia
author_facet	Giulia A. Restivo Marta Pillon Lara Mussolin Clara Mosa Angela Guarina Angela Trizzino Salvatore Ialuna Elisa Carraro Emanuele S.G. D’Amore Giovanna Russo Caterina Elia Maurizio Mascarin Adriana Zangara Paolo D’Angelo Piero Farruggia
author_sort	Giulia A. Restivo
title	Primary breast lymphoma of childhood: a case report and review of literature
title_short	Primary breast lymphoma of childhood: a case report and review of literature
title_full	Primary breast lymphoma of childhood: a case report and review of literature
title_fullStr	Primary breast lymphoma of childhood: a case report and review of literature
title_full_unstemmed	Primary breast lymphoma of childhood: a case report and review of literature
title_sort	primary breast lymphoma of childhood: a case report and review of literature
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c7daf17de31e41b3869e8fb6fbade631
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Primary breast lymphoma of childhood: a case report and review of literature

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