Inflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study

Lina Zhou, Xiancang Ma, Wei Wang Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Wei WangDepartment of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong U...

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Autores principales:	Zhou L, Ma X, Wang W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	major depressive disorder inflammation coronary heart disease complete blood count framingham risk score Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c7db4a97747849ca9c4097793dba8876
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spelling	oai:doaj.org-article:c7db4a97747849ca9c4097793dba88762021-12-02T06:42:06ZInflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study1178-2021https://doaj.org/article/c7db4a97747849ca9c4097793dba88762020-01-01T00:00:00Zhttps://www.dovepress.com/inflammation-and-coronary-heart-disease-risk-in-patients-with-depressi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lina Zhou, Xiancang Ma, Wei Wang Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Wei WangDepartment of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, Shaanxi, People’s Republic of ChinaTel +86 02985323112Email xianwv@sina.comObjective: The risk of coronary heart disease (CHD) in patients with major depressive disorder (MDD) is higher than that in the general population. However, the mechanisms underlying the increased CHD risk in patients with MDD remain unclear. Inflammation plays an important role in the pathogenesis of MDD and CHD. Therefore, we explored the relationship between inflammatory biomarkers and CHD risk in patients with MDD.Methods: We included 454 patients with acute MDD and 458 controls that matched the sample in age and gender. A readily available complete blood count was used to reflect inflammation, and the risk of CHD was assessed using the Framingham risk score.Results: The results showed that patients with MDD showed low-grade inflammation with an elevated platelet (p<0.001) and monocyte count (p<0.001), high platelet/lymphocyte (p=0.003) and monocyte/lymphocyte ratios (p<0.001), and a raised systemic immune-inflammation index (p=0.002). In addition, monocyte count was the only factor significantly associated with CHD risk in patients with MDD (B=7.521, 95% CI: 3.409–11.633, t=3.594, p<0.001).Conclusion: Collectively, the results of this study support the hypothesis that MDD is systemic inflammation, and suggest that monocyte count predicts the risk of CHD in patients with MDD.Keywords: major depressive disorder, inflammation, coronary heart disease, complete blood count, Framingham risk scoreZhou LMa XWang WDove Medical Pressarticlemajor depressive disorderinflammationcoronary heart diseasecomplete blood countframingham risk scoreNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 81-86 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depressive disorder inflammation coronary heart disease complete blood count framingham risk score Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	major depressive disorder inflammation coronary heart disease complete blood count framingham risk score Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhou L Ma X Wang W Inflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study
description	Lina Zhou, Xiancang Ma, Wei Wang Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Wei WangDepartment of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, Shaanxi, People’s Republic of ChinaTel +86 02985323112Email xianwv@sina.comObjective: The risk of coronary heart disease (CHD) in patients with major depressive disorder (MDD) is higher than that in the general population. However, the mechanisms underlying the increased CHD risk in patients with MDD remain unclear. Inflammation plays an important role in the pathogenesis of MDD and CHD. Therefore, we explored the relationship between inflammatory biomarkers and CHD risk in patients with MDD.Methods: We included 454 patients with acute MDD and 458 controls that matched the sample in age and gender. A readily available complete blood count was used to reflect inflammation, and the risk of CHD was assessed using the Framingham risk score.Results: The results showed that patients with MDD showed low-grade inflammation with an elevated platelet (p<0.001) and monocyte count (p<0.001), high platelet/lymphocyte (p=0.003) and monocyte/lymphocyte ratios (p<0.001), and a raised systemic immune-inflammation index (p=0.002). In addition, monocyte count was the only factor significantly associated with CHD risk in patients with MDD (B=7.521, 95% CI: 3.409–11.633, t=3.594, p<0.001).Conclusion: Collectively, the results of this study support the hypothesis that MDD is systemic inflammation, and suggest that monocyte count predicts the risk of CHD in patients with MDD.Keywords: major depressive disorder, inflammation, coronary heart disease, complete blood count, Framingham risk score
format	article
author	Zhou L Ma X Wang W
author_facet	Zhou L Ma X Wang W
author_sort	Zhou L
title	Inflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study
title_short	Inflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study
title_full	Inflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study
title_fullStr	Inflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study
title_full_unstemmed	Inflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study
title_sort	inflammation and coronary heart disease risk in patients with depression in china mainland: a cross-sectional study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/c7db4a97747849ca9c4097793dba8876
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Inflammation and Coronary Heart Disease Risk in Patients with Depression in China Mainland: A Cross-Sectional Study

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