Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice

Heterotopic ossification (HO) is a painful disease of unknown etiology characterized by extraskeletal bone formation after injury. Here the authors show that TGF-β is increased in HO lesions, where it promotes the early stages of HO pathology, and demonstrate that TGF-β inhibition ameliorates HO in...

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Autores principales:	Xiao Wang, Fengfeng Li, Liang Xie, Janet Crane, Gehua Zhen, Yuji Mishina, Ruoxian Deng, Bo Gao, Hao Chen, Shen Liu, Ping Yang, Manman Gao, Manli Tu, Yiguo Wang, Mei Wan, Cunyi Fan, Xu Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c7db988c5bea48faaaf943a775bc00e3
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spelling	oai:doaj.org-article:c7db988c5bea48faaaf943a775bc00e32021-12-02T14:38:48ZInhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice10.1038/s41467-018-02988-52041-1723https://doaj.org/article/c7db988c5bea48faaaf943a775bc00e32018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02988-5https://doaj.org/toc/2041-1723Heterotopic ossification (HO) is a painful disease of unknown etiology characterized by extraskeletal bone formation after injury. Here the authors show that TGF-β is increased in HO lesions, where it promotes the early stages of HO pathology, and demonstrate that TGF-β inhibition ameliorates HO in mice.Xiao WangFengfeng LiLiang XieJanet CraneGehua ZhenYuji MishinaRuoxian DengBo GaoHao ChenShen LiuPing YangManman GaoManli TuYiguo WangMei WanCunyi FanXu CaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao Wang Fengfeng Li Liang Xie Janet Crane Gehua Zhen Yuji Mishina Ruoxian Deng Bo Gao Hao Chen Shen Liu Ping Yang Manman Gao Manli Tu Yiguo Wang Mei Wan Cunyi Fan Xu Cao Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice
description	Heterotopic ossification (HO) is a painful disease of unknown etiology characterized by extraskeletal bone formation after injury. Here the authors show that TGF-β is increased in HO lesions, where it promotes the early stages of HO pathology, and demonstrate that TGF-β inhibition ameliorates HO in mice.
format	article
author	Xiao Wang Fengfeng Li Liang Xie Janet Crane Gehua Zhen Yuji Mishina Ruoxian Deng Bo Gao Hao Chen Shen Liu Ping Yang Manman Gao Manli Tu Yiguo Wang Mei Wan Cunyi Fan Xu Cao
author_facet	Xiao Wang Fengfeng Li Liang Xie Janet Crane Gehua Zhen Yuji Mishina Ruoxian Deng Bo Gao Hao Chen Shen Liu Ping Yang Manman Gao Manli Tu Yiguo Wang Mei Wan Cunyi Fan Xu Cao
author_sort	Xiao Wang
title	Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice
title_short	Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice
title_full	Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice
title_fullStr	Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice
title_full_unstemmed	Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice
title_sort	inhibition of overactive tgf-β attenuates progression of heterotopic ossification in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c7db988c5bea48faaaf943a775bc00e3
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Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice

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