Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress

Hypertension impairs the function of the kidney and its vasculature. Adrenergic activation is involved in these processes by promoting oxidative stress and mitochondrial dysfunction. Thus, the targeting of mitochondrial function and mitochondrial oxidative stress may be an approach to alleviate hype...

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Autores principales:	Cristian Adrián Márquez-Ramírez, Berenice Eridani Olmos-Orizaba, Claudia Isabel García-Berumen, Elizabeth Calderón-Cortés, Rocío Montoya-Pérez, Alfredo Saavedra-Molina, Alain Raimundo Rodríguez-Orozco, Christian Cortés-Rojo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hypertension prazosin adrenergic receptors kidney disease complex I mitochondria Science Q
Acceso en línea:	https://doaj.org/article/c7dd9aa4ebe843cda49aa7fc339cd460
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spelling	oai:doaj.org-article:c7dd9aa4ebe843cda49aa7fc339cd4602021-11-25T18:10:28ZAvocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress10.3390/life111111222075-1729https://doaj.org/article/c7dd9aa4ebe843cda49aa7fc339cd4602021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1122https://doaj.org/toc/2075-1729Hypertension impairs the function of the kidney and its vasculature. Adrenergic activation is involved in these processes by promoting oxidative stress and mitochondrial dysfunction. Thus, the targeting of mitochondrial function and mitochondrial oxidative stress may be an approach to alleviate hypertensive kidney damage. Avocado oil, a source of oleic acid and antioxidants, improves mitochondrial dysfunction, decreases mitochondrial oxidative stress, and enhances vascular function in hypertensive rats. However, whether avocado oil improves the function of renal vasculature during the adrenergic stimulation, and if this is related to improvement in renal damage and enhancement of mitochondrial activity is unknown. Thus, the effects of avocado oil on renal vascular responses to adrenergic stimulation, mitochondrial dysfunction, oxidative stress, and renal damage were compared with prazosin, an antagonist of α<sub>1</sub>-adrenoceptors, in hypertensive rats induced by L-NAME. Avocado oil or prazosin decreased blood pressure, improved endothelium—dependent renal vasodilation, prevented mitochondrial dysfunction and kidney damage in hypertensive rats. However, avocado oil, but not prazosin, decreased mitochondrial ROS generation and improved the redox state of mitochondrial glutathione. These results suggest that avocado oil and prazosin prevented hypertensive renal damage due to the improvement in mitochondrial function.Cristian Adrián Márquez-RamírezBerenice Eridani Olmos-OrizabaClaudia Isabel García-BerumenElizabeth Calderón-CortésRocío Montoya-PérezAlfredo Saavedra-MolinaAlain Raimundo Rodríguez-OrozcoChristian Cortés-RojoMDPI AGarticlehypertensionprazosinadrenergic receptorskidney diseasecomplex ImitochondriaScienceQENLife, Vol 11, Iss 1122, p 1122 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypertension prazosin adrenergic receptors kidney disease complex I mitochondria Science Q
spellingShingle	hypertension prazosin adrenergic receptors kidney disease complex I mitochondria Science Q Cristian Adrián Márquez-Ramírez Berenice Eridani Olmos-Orizaba Claudia Isabel García-Berumen Elizabeth Calderón-Cortés Rocío Montoya-Pérez Alfredo Saavedra-Molina Alain Raimundo Rodríguez-Orozco Christian Cortés-Rojo Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress
description	Hypertension impairs the function of the kidney and its vasculature. Adrenergic activation is involved in these processes by promoting oxidative stress and mitochondrial dysfunction. Thus, the targeting of mitochondrial function and mitochondrial oxidative stress may be an approach to alleviate hypertensive kidney damage. Avocado oil, a source of oleic acid and antioxidants, improves mitochondrial dysfunction, decreases mitochondrial oxidative stress, and enhances vascular function in hypertensive rats. However, whether avocado oil improves the function of renal vasculature during the adrenergic stimulation, and if this is related to improvement in renal damage and enhancement of mitochondrial activity is unknown. Thus, the effects of avocado oil on renal vascular responses to adrenergic stimulation, mitochondrial dysfunction, oxidative stress, and renal damage were compared with prazosin, an antagonist of α<sub>1</sub>-adrenoceptors, in hypertensive rats induced by L-NAME. Avocado oil or prazosin decreased blood pressure, improved endothelium—dependent renal vasodilation, prevented mitochondrial dysfunction and kidney damage in hypertensive rats. However, avocado oil, but not prazosin, decreased mitochondrial ROS generation and improved the redox state of mitochondrial glutathione. These results suggest that avocado oil and prazosin prevented hypertensive renal damage due to the improvement in mitochondrial function.
format	article
author	Cristian Adrián Márquez-Ramírez Berenice Eridani Olmos-Orizaba Claudia Isabel García-Berumen Elizabeth Calderón-Cortés Rocío Montoya-Pérez Alfredo Saavedra-Molina Alain Raimundo Rodríguez-Orozco Christian Cortés-Rojo
author_facet	Cristian Adrián Márquez-Ramírez Berenice Eridani Olmos-Orizaba Claudia Isabel García-Berumen Elizabeth Calderón-Cortés Rocío Montoya-Pérez Alfredo Saavedra-Molina Alain Raimundo Rodríguez-Orozco Christian Cortés-Rojo
author_sort	Cristian Adrián Márquez-Ramírez
title	Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress
title_short	Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress
title_full	Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress
title_fullStr	Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress
title_full_unstemmed	Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress
title_sort	avocado oil prevents kidney injury and normalizes renal vasodilation after adrenergic stimulation in hypertensive rats: probable role of improvement in mitochondrial dysfunction and oxidative stress
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c7dd9aa4ebe843cda49aa7fc339cd460
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Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress

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