INFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS

We have assumed, that serum production of biological markers that are significantly reflecting a risk degree for atherosclerotic process and acute coronary events may be modified by functional polymorphisms of a functional complex of genes that may be involved into inflammatory process and influence...

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Autores principales:	A. V. Shevchenko, V. F. Prokofyev, Yu. I. Ragino, A. M. Chernjavski, M. I. Voevoda, V. I. Konenkov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	atherosclerosis cytokine genes polymorphism biochemical parameters Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c7e1278d399a443888b996bbf88a629c
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spelling	oai:doaj.org-article:c7e1278d399a443888b996bbf88a629c2021-11-18T08:03:43ZINFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS1563-06252313-741X10.15789/1563-0625-2014-4-333-344https://doaj.org/article/c7e1278d399a443888b996bbf88a629c2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/699https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe have assumed, that serum production of biological markers that are significantly reflecting a risk degree for atherosclerotic process and acute coronary events may be modified by functional polymorphisms of a functional complex of genes that may be involved into inflammatory process and influence mutual regulation of their production. Therefore, we have assayed a number of appropriate gene polymorphisms and assessed frequency distribution for several promoter genotypes and their combinations, e.c., TNF-A863C; TNF-A308G; TNF-A238G; IL1B C-31T; IL1B-C511T; IL4-C590T; IL6-C174G; IL10A-1082G, IL10-А592C genes, regulatory sites of VEGF-А2578С, VEGF+Т936 gene variants. We have also measured serum levels of TNFα, IL-1β, IL-6, IL-8, IL-1 receptor antagonist (IL-1ra), C-reactive protein, soluble CD40 ligand receptor (sCD40L) in the patients with atherosclerosis. In general, it has been shown that contribution of single cytokine genotypes to the association with level of their production is much lower, than odds ratio of changed protein production associated with a compound genotype.A. V. ShevchenkoV. F. ProkofyevYu. I. RaginoA. M. ChernjavskiM. I. VoevodaV. I. KonenkovSPb RAACIarticleatherosclerosiscytokine genespolymorphismbiochemical parametersImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 4, Pp 333-344 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	atherosclerosis cytokine genes polymorphism biochemical parameters Immunologic diseases. Allergy RC581-607
spellingShingle	atherosclerosis cytokine genes polymorphism biochemical parameters Immunologic diseases. Allergy RC581-607 A. V. Shevchenko V. F. Prokofyev Yu. I. Ragino A. M. Chernjavski M. I. Voevoda V. I. Konenkov INFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS
description	We have assumed, that serum production of biological markers that are significantly reflecting a risk degree for atherosclerotic process and acute coronary events may be modified by functional polymorphisms of a functional complex of genes that may be involved into inflammatory process and influence mutual regulation of their production. Therefore, we have assayed a number of appropriate gene polymorphisms and assessed frequency distribution for several promoter genotypes and their combinations, e.c., TNF-A863C; TNF-A308G; TNF-A238G; IL1B C-31T; IL1B-C511T; IL4-C590T; IL6-C174G; IL10A-1082G, IL10-А592C genes, regulatory sites of VEGF-А2578С, VEGF+Т936 gene variants. We have also measured serum levels of TNFα, IL-1β, IL-6, IL-8, IL-1 receptor antagonist (IL-1ra), C-reactive protein, soluble CD40 ligand receptor (sCD40L) in the patients with atherosclerosis. In general, it has been shown that contribution of single cytokine genotypes to the association with level of their production is much lower, than odds ratio of changed protein production associated with a compound genotype.
format	article
author	A. V. Shevchenko V. F. Prokofyev Yu. I. Ragino A. M. Chernjavski M. I. Voevoda V. I. Konenkov
author_facet	A. V. Shevchenko V. F. Prokofyev Yu. I. Ragino A. M. Chernjavski M. I. Voevoda V. I. Konenkov
author_sort	A. V. Shevchenko
title	INFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS
title_short	INFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS
title_full	INFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS
title_fullStr	INFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS
title_full_unstemmed	INFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS
title_sort	inflammatory cytocines genes polymorphism association with serum levels of biochemical markers at the coronary atherosclerosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/c7e1278d399a443888b996bbf88a629c
work_keys_str_mv	AT avshevchenko inflammatorycytocinesgenespolymorphismassociationwithserumlevelsofbiochemicalmarkersatthecoronaryatherosclerosis AT vfprokofyev inflammatorycytocinesgenespolymorphismassociationwithserumlevelsofbiochemicalmarkersatthecoronaryatherosclerosis AT yuiragino inflammatorycytocinesgenespolymorphismassociationwithserumlevelsofbiochemicalmarkersatthecoronaryatherosclerosis AT amchernjavski inflammatorycytocinesgenespolymorphismassociationwithserumlevelsofbiochemicalmarkersatthecoronaryatherosclerosis AT mivoevoda inflammatorycytocinesgenespolymorphismassociationwithserumlevelsofbiochemicalmarkersatthecoronaryatherosclerosis AT vikonenkov inflammatorycytocinesgenespolymorphismassociationwithserumlevelsofbiochemicalmarkersatthecoronaryatherosclerosis
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INFLAMMATORY CYTOCINES GENES POLYMORPHISM ASSOCIATION WITH SERUM LEVELS OF BIOCHEMICAL MARKERS AT THE CORONARY ATHEROSCLEROSIS

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