Mouse Acidic Chitinase Effectively Degrades Random-Type Chitosan to Chitooligosaccharides of Variable Lengths under Stomach and Lung Tissue pH Conditions

Mouse Acidic Chitinase Effectively Degrades Random-Type Chitosan to Chitooligosaccharides of Variable Lengths under Stomach and Lung Tissue pH Conditions

Chitooligosaccharides exhibit several biomedical activities, such as inflammation and tumorigenesis reduction in mammals. The mechanism of the chitooligosaccharides’ formation in vivo has been, however, poorly understood. Here we report that mouse acidic chitinase (Chia), which is widely expressed i...

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Main Authors: Satoshi Wakita, Yasusato Sugahara, Masayuki Nakamura, Syunsuke Kobayashi, Kazuhisa Matsuda, Chinatsu Takasaki, Masahiro Kimura, Yuta Kida, Maiko Uehara, Eri Tabata, Koji Hiraoka, Shiro Seki, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
acidic chitinase
block-type chitosan
chitin
chitooligosaccharides
FACE method
random-type chitosan
Organic chemistry
QD241-441
Online Access:https://doaj.org/article/c7e3c168daf14ca5936ba77f5e7f2ff1
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https://doaj.org/article/c7e3c168daf14ca5936ba77f5e7f2ff1

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