Safety and data quality of EEG recorded simultaneously with multi-band fMRI.

<h4>Purpose</h4>Simultaneously recorded electroencephalography and functional magnetic resonance imaging (EEG-fMRI) is highly informative yet technically challenging. Until recently, there has been little information about EEG data quality and safety when used with newer multi-band (MB)...

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Autores principales:	Maximillian K Egan, Ryan Larsen, Jonathan Wirsich, Brad P Sutton, Sepideh Sadaghiani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7e4416e0bce443f9332337a9c27ad01
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spelling	oai:doaj.org-article:c7e4416e0bce443f9332337a9c27ad012021-12-02T20:05:13ZSafety and data quality of EEG recorded simultaneously with multi-band fMRI.1932-620310.1371/journal.pone.0238485https://doaj.org/article/c7e4416e0bce443f9332337a9c27ad012021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0238485https://doaj.org/toc/1932-6203<h4>Purpose</h4>Simultaneously recorded electroencephalography and functional magnetic resonance imaging (EEG-fMRI) is highly informative yet technically challenging. Until recently, there has been little information about EEG data quality and safety when used with newer multi-band (MB) fMRI sequences. Here, we measure the relative heating of a MB protocol compared with a standard single-band (SB) protocol considered to be safe. We also evaluated EEG quality recorded concurrently with the MB protocol on humans.<h4>Materials and methods</h4>We compared radiofrequency (RF)-related heating at multiple electrodes and magnetic field magnitude, B1+RMS, of a MB fMRI sequence with whole-brain coverage (TR = 440 ms, MB factor = 4) against a previously recommended, safe SB sequence using a phantom outfitted with a 64-channel EEG cap. Next, 9 human subjects underwent eyes-closed resting state EEG-fMRI using the MB sequence. Additionally, in three of the subjects resting state EEG was recorded also during the SB sequence and in an fMRI-free condition to directly compare EEG data quality across scanning conditions. EEG data quality was assessed by the ability to remove gradient and cardioballistic artifacts along with a clean spectrogram.<h4>Results</h4>The heating induced by the MB sequence was lower than that of the SB sequence by a factor of 0.73 ± 0.38. This is consistent with an expected heating ratio of 0.64, calculated from the square of the ratio of B1+RMS values of the sequences. In the resting state EEG data, gradient and cardioballistic artifacts were successfully removed using traditional template subtraction. All subjects showed an individual alpha peak in the spectrogram with a posterior topography characteristic of eyes-closed EEG. The success of artifact rejection for the MB sequence was comparable to that in traditional SB sequences.<h4>Conclusions</h4>Our study shows that B1+RMS is a useful indication of the relative heating of fMRI protocols. This observation indicates that simultaneous EEG-fMRI recordings using this MB sequence can be safe in terms of RF-related heating, and that EEG data recorded using this sequence is of acceptable quality after traditional artifact removal techniques.Maximillian K EganRyan LarsenJonathan WirsichBrad P SuttonSepideh SadaghianiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0238485 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maximillian K Egan Ryan Larsen Jonathan Wirsich Brad P Sutton Sepideh Sadaghiani Safety and data quality of EEG recorded simultaneously with multi-band fMRI.
description	<h4>Purpose</h4>Simultaneously recorded electroencephalography and functional magnetic resonance imaging (EEG-fMRI) is highly informative yet technically challenging. Until recently, there has been little information about EEG data quality and safety when used with newer multi-band (MB) fMRI sequences. Here, we measure the relative heating of a MB protocol compared with a standard single-band (SB) protocol considered to be safe. We also evaluated EEG quality recorded concurrently with the MB protocol on humans.<h4>Materials and methods</h4>We compared radiofrequency (RF)-related heating at multiple electrodes and magnetic field magnitude, B1+RMS, of a MB fMRI sequence with whole-brain coverage (TR = 440 ms, MB factor = 4) against a previously recommended, safe SB sequence using a phantom outfitted with a 64-channel EEG cap. Next, 9 human subjects underwent eyes-closed resting state EEG-fMRI using the MB sequence. Additionally, in three of the subjects resting state EEG was recorded also during the SB sequence and in an fMRI-free condition to directly compare EEG data quality across scanning conditions. EEG data quality was assessed by the ability to remove gradient and cardioballistic artifacts along with a clean spectrogram.<h4>Results</h4>The heating induced by the MB sequence was lower than that of the SB sequence by a factor of 0.73 ± 0.38. This is consistent with an expected heating ratio of 0.64, calculated from the square of the ratio of B1+RMS values of the sequences. In the resting state EEG data, gradient and cardioballistic artifacts were successfully removed using traditional template subtraction. All subjects showed an individual alpha peak in the spectrogram with a posterior topography characteristic of eyes-closed EEG. The success of artifact rejection for the MB sequence was comparable to that in traditional SB sequences.<h4>Conclusions</h4>Our study shows that B1+RMS is a useful indication of the relative heating of fMRI protocols. This observation indicates that simultaneous EEG-fMRI recordings using this MB sequence can be safe in terms of RF-related heating, and that EEG data recorded using this sequence is of acceptable quality after traditional artifact removal techniques.
format	article
author	Maximillian K Egan Ryan Larsen Jonathan Wirsich Brad P Sutton Sepideh Sadaghiani
author_facet	Maximillian K Egan Ryan Larsen Jonathan Wirsich Brad P Sutton Sepideh Sadaghiani
author_sort	Maximillian K Egan
title	Safety and data quality of EEG recorded simultaneously with multi-band fMRI.
title_short	Safety and data quality of EEG recorded simultaneously with multi-band fMRI.
title_full	Safety and data quality of EEG recorded simultaneously with multi-band fMRI.
title_fullStr	Safety and data quality of EEG recorded simultaneously with multi-band fMRI.
title_full_unstemmed	Safety and data quality of EEG recorded simultaneously with multi-band fMRI.
title_sort	safety and data quality of eeg recorded simultaneously with multi-band fmri.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c7e4416e0bce443f9332337a9c27ad01
work_keys_str_mv	AT maximilliankegan safetyanddataqualityofeegrecordedsimultaneouslywithmultibandfmri AT ryanlarsen safetyanddataqualityofeegrecordedsimultaneouslywithmultibandfmri AT jonathanwirsich safetyanddataqualityofeegrecordedsimultaneouslywithmultibandfmri AT bradpsutton safetyanddataqualityofeegrecordedsimultaneouslywithmultibandfmri AT sepidehsadaghiani safetyanddataqualityofeegrecordedsimultaneouslywithmultibandfmri
_version_	1718375506532892672

Safety and data quality of EEG recorded simultaneously with multi-band fMRI.

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