Prospective investigation of polyomavirus infection and the risk of adult glioma

Abstract Glioma is an aggressive primary tumor of the brain with a poorly understood etiology. We studied the association of 4 human polyomaviruses (HPyV)—JC virus (JCV), BK virus (BKV), human polyomavirus 6 (HPyV6), and Merkel cell polyomavirus (MCPyV) with glioma risk within the Cancer Prevention...

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Autores principales:	Kathleen M. Egan, Youngchul Kim, Noemi Bender, James M. Hodge, Anna E. Coghill, Stephanie A. Smith-Warner, Dana E. Rollison, Lauren R. Teras, Tom K. Grimsrud, Tim Waterboer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7e69f91592248d6ac0f7c5a0a840ccf
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spelling	oai:doaj.org-article:c7e69f91592248d6ac0f7c5a0a840ccf2021-12-02T14:29:03ZProspective investigation of polyomavirus infection and the risk of adult glioma10.1038/s41598-021-89133-32045-2322https://doaj.org/article/c7e69f91592248d6ac0f7c5a0a840ccf2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89133-3https://doaj.org/toc/2045-2322Abstract Glioma is an aggressive primary tumor of the brain with a poorly understood etiology. We studied the association of 4 human polyomaviruses (HPyV)—JC virus (JCV), BK virus (BKV), human polyomavirus 6 (HPyV6), and Merkel cell polyomavirus (MCPyV) with glioma risk within the Cancer Prevention Study II in the US (CPS-II) and the Janus Serum Bank in Norway. Cohort participants subsequently diagnosed with glioma from the CPS-II (n = 37) and Janus Serum Bank (n = 323), a median of 6.9 and 15.4 years after blood collection, respectively, were matched to individual controls on age, sex, and date of blood draw. Serum antibodies to the major viral capsid protein (VP1) were used to establish infection history for each polyomavirus. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. In the Janus Serum Bank, MCPyV infection was associated with a higher risk of glioma overall (OR: 1.56; 95% CI 1.10, 2.19). A modest, nonsignificant positive association with MCPyV infection was also observed in CPS-II (OR: 1.29; 95% CI 0.54, 3.08). In both cohorts, glioma risk was not significantly related to infection with JCV, BKV or HPyV6. The present study suggests that MCPyV infection may increase glioma risk.Kathleen M. EganYoungchul KimNoemi BenderJames M. HodgeAnna E. CoghillStephanie A. Smith-WarnerDana E. RollisonLauren R. TerasTom K. GrimsrudTim WaterboerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kathleen M. Egan Youngchul Kim Noemi Bender James M. Hodge Anna E. Coghill Stephanie A. Smith-Warner Dana E. Rollison Lauren R. Teras Tom K. Grimsrud Tim Waterboer Prospective investigation of polyomavirus infection and the risk of adult glioma
description	Abstract Glioma is an aggressive primary tumor of the brain with a poorly understood etiology. We studied the association of 4 human polyomaviruses (HPyV)—JC virus (JCV), BK virus (BKV), human polyomavirus 6 (HPyV6), and Merkel cell polyomavirus (MCPyV) with glioma risk within the Cancer Prevention Study II in the US (CPS-II) and the Janus Serum Bank in Norway. Cohort participants subsequently diagnosed with glioma from the CPS-II (n = 37) and Janus Serum Bank (n = 323), a median of 6.9 and 15.4 years after blood collection, respectively, were matched to individual controls on age, sex, and date of blood draw. Serum antibodies to the major viral capsid protein (VP1) were used to establish infection history for each polyomavirus. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. In the Janus Serum Bank, MCPyV infection was associated with a higher risk of glioma overall (OR: 1.56; 95% CI 1.10, 2.19). A modest, nonsignificant positive association with MCPyV infection was also observed in CPS-II (OR: 1.29; 95% CI 0.54, 3.08). In both cohorts, glioma risk was not significantly related to infection with JCV, BKV or HPyV6. The present study suggests that MCPyV infection may increase glioma risk.
format	article
author	Kathleen M. Egan Youngchul Kim Noemi Bender James M. Hodge Anna E. Coghill Stephanie A. Smith-Warner Dana E. Rollison Lauren R. Teras Tom K. Grimsrud Tim Waterboer
author_facet	Kathleen M. Egan Youngchul Kim Noemi Bender James M. Hodge Anna E. Coghill Stephanie A. Smith-Warner Dana E. Rollison Lauren R. Teras Tom K. Grimsrud Tim Waterboer
author_sort	Kathleen M. Egan
title	Prospective investigation of polyomavirus infection and the risk of adult glioma
title_short	Prospective investigation of polyomavirus infection and the risk of adult glioma
title_full	Prospective investigation of polyomavirus infection and the risk of adult glioma
title_fullStr	Prospective investigation of polyomavirus infection and the risk of adult glioma
title_full_unstemmed	Prospective investigation of polyomavirus infection and the risk of adult glioma
title_sort	prospective investigation of polyomavirus infection and the risk of adult glioma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c7e69f91592248d6ac0f7c5a0a840ccf
work_keys_str_mv	AT kathleenmegan prospectiveinvestigationofpolyomavirusinfectionandtheriskofadultglioma AT youngchulkim prospectiveinvestigationofpolyomavirusinfectionandtheriskofadultglioma AT noemibender prospectiveinvestigationofpolyomavirusinfectionandtheriskofadultglioma AT jamesmhodge prospectiveinvestigationofpolyomavirusinfectionandtheriskofadultglioma AT annaecoghill prospectiveinvestigationofpolyomavirusinfectionandtheriskofadultglioma AT stephanieasmithwarner prospectiveinvestigationofpolyomavirusinfectionandtheriskofadultglioma AT danaerollison prospectiveinvestigationofpolyomavirusinfectionandtheriskofadultglioma AT laurenrteras prospectiveinvestigationofpolyomavirusinfectionandtheriskofadultglioma AT tomkgrimsrud prospectiveinvestigationofpolyomavirusinfectionandtheriskofadultglioma AT timwaterboer prospectiveinvestigationofpolyomavirusinfectionandtheriskofadultglioma
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Prospective investigation of polyomavirus infection and the risk of adult glioma

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