Variation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus

Abstract The high degree of conservation of toll-like receptors (TLRs), and yet their subtle variations for better adaptation of species in the host–pathogen arms race make them worthy candidates for understanding evolution. We have attempted to track the trend of TLR evolution in the most diverse v...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Manisha Priyam, Sanjay K. Gupta, Biplab Sarkar, T. R. Sharma, A. Pattanayak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7e960af82b74e5588e2e7b849da16c8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c7e960af82b74e5588e2e7b849da16c8
record_format	dspace
spelling	oai:doaj.org-article:c7e960af82b74e5588e2e7b849da16c82021-12-02T16:08:54ZVariation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus10.1038/s41598-020-78347-62045-2322https://doaj.org/article/c7e960af82b74e5588e2e7b849da16c82020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78347-6https://doaj.org/toc/2045-2322Abstract The high degree of conservation of toll-like receptors (TLRs), and yet their subtle variations for better adaptation of species in the host–pathogen arms race make them worthy candidates for understanding evolution. We have attempted to track the trend of TLR evolution in the most diverse vertebrate group—teleosts, where Clarias batrachus was given emphasis, considering its traits for terrestrial adaptation. Eleven C. batrachus TLRs (TLR1, 2, 3, 5, 7, 8 9, 13, 22, 25, 26) were identified in this study which clustered in proximity to its Siluriformes relative orthologues in the phylogenetic analysis of 228 TLRs from 25 teleosts. Ten TLRs (TLR1, 2, 3, 5, 7, 8 9, 13, 21, 22) with at least 15 member orthologues for each alignment were processed for selection pressure and coevolutionary analysis. TLR1, 7, 8 and 9 were found to be under positive selection in the alignment-wide test. TLR1 also showed maximum episodic diversification in its clades while the teleost group Eupercaria showed the maximum divergence in their TLR repertoire. Episodic diversification was evident in C. batrachus TLR1 and 7 alignments. These results present a strong evidence of a divergent TLR repertoire in teleosts which may be contributing towards species-specific variation in TLR functions.Manisha PriyamSanjay K. GuptaBiplab SarkarT. R. SharmaA. PattanayakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manisha Priyam Sanjay K. Gupta Biplab Sarkar T. R. Sharma A. Pattanayak Variation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus
description	Abstract The high degree of conservation of toll-like receptors (TLRs), and yet their subtle variations for better adaptation of species in the host–pathogen arms race make them worthy candidates for understanding evolution. We have attempted to track the trend of TLR evolution in the most diverse vertebrate group—teleosts, where Clarias batrachus was given emphasis, considering its traits for terrestrial adaptation. Eleven C. batrachus TLRs (TLR1, 2, 3, 5, 7, 8 9, 13, 22, 25, 26) were identified in this study which clustered in proximity to its Siluriformes relative orthologues in the phylogenetic analysis of 228 TLRs from 25 teleosts. Ten TLRs (TLR1, 2, 3, 5, 7, 8 9, 13, 21, 22) with at least 15 member orthologues for each alignment were processed for selection pressure and coevolutionary analysis. TLR1, 7, 8 and 9 were found to be under positive selection in the alignment-wide test. TLR1 also showed maximum episodic diversification in its clades while the teleost group Eupercaria showed the maximum divergence in their TLR repertoire. Episodic diversification was evident in C. batrachus TLR1 and 7 alignments. These results present a strong evidence of a divergent TLR repertoire in teleosts which may be contributing towards species-specific variation in TLR functions.
format	article
author	Manisha Priyam Sanjay K. Gupta Biplab Sarkar T. R. Sharma A. Pattanayak
author_facet	Manisha Priyam Sanjay K. Gupta Biplab Sarkar T. R. Sharma A. Pattanayak
author_sort	Manisha Priyam
title	Variation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus
title_short	Variation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus
title_full	Variation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus
title_fullStr	Variation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus
title_full_unstemmed	Variation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus
title_sort	variation in selection constraints on teleost tlrs with emphasis on their repertoire in the walking catfish, clarias batrachus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c7e960af82b74e5588e2e7b849da16c8
work_keys_str_mv	AT manishapriyam variationinselectionconstraintsonteleosttlrswithemphasisontheirrepertoireinthewalkingcatfishclariasbatrachus AT sanjaykgupta variationinselectionconstraintsonteleosttlrswithemphasisontheirrepertoireinthewalkingcatfishclariasbatrachus AT biplabsarkar variationinselectionconstraintsonteleosttlrswithemphasisontheirrepertoireinthewalkingcatfishclariasbatrachus AT trsharma variationinselectionconstraintsonteleosttlrswithemphasisontheirrepertoireinthewalkingcatfishclariasbatrachus AT apattanayak variationinselectionconstraintsonteleosttlrswithemphasisontheirrepertoireinthewalkingcatfishclariasbatrachus
_version_	1718384495038562304

Variation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus

Ejemplares similares