The dual role of platelet‐innate immune cell interactions in thrombo‐inflammation

Abstract Beyond their role in hemostasis and thrombosis, platelets are increasingly recognized as key regulators of the inflammatory response under sterile and infectious conditions. Both platelet receptors and secretion are critical for these functions and contribute to their interaction with the e...

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Autores principales:	Julie Rayes, Joshua H. Bourne, Alexander Brill, Steve P. Watson
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2020
Materias:	immune cells inflammation platelets thrombo‐inflammation thrombosis Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/c7ec012f308a4eb1861951ab4c9a7ff8
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spelling	oai:doaj.org-article:c7ec012f308a4eb1861951ab4c9a7ff82021-11-15T06:10:44ZThe dual role of platelet‐innate immune cell interactions in thrombo‐inflammation2475-037910.1002/rth2.12266https://doaj.org/article/c7ec012f308a4eb1861951ab4c9a7ff82020-01-01T00:00:00Zhttps://doi.org/10.1002/rth2.12266https://doaj.org/toc/2475-0379Abstract Beyond their role in hemostasis and thrombosis, platelets are increasingly recognized as key regulators of the inflammatory response under sterile and infectious conditions. Both platelet receptors and secretion are critical for these functions and contribute to their interaction with the endothelium and innate immune system. Platelet‐leukocyte interactions are increased in thrombo‐inflammatory diseases and are sensitive biomarkers for platelet activation and targets for the development of new therapies. The crosstalk between platelets and innate immune cells promotes thrombosis, inflammation, and tissue damage. However, recent studies have shown that these interactions also regulate the resolution of inflammation, tissue repair, and wound healing. Many of the platelet and leukocyte receptors involved in these bidirectional interactions are not selective for a subset of immune cells. However, specific heterotypic interactions occur in different vascular beds and inflammatory conditions, raising the possibility of disease‐ and organ‐specific pathways of intervention. In this review, we highlight and discuss prominent and emerging interrelationships between platelets and innate immune cells and their dual role in the regulation of the inflammatory response in sterile and infectious thrombo‐inflammatory diseases. A better understanding of the functional relevance of these interactions in different vascular beds may provide opportunities for successful therapeutic interventions to regulate the development, progression, and chronicity of various pathological processes.Julie RayesJoshua H. BourneAlexander BrillSteve P. WatsonWileyarticleimmune cellsinflammationplateletsthrombo‐inflammationthrombosisDiseases of the blood and blood-forming organsRC633-647.5ENResearch and Practice in Thrombosis and Haemostasis, Vol 4, Iss 1, Pp 23-35 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	immune cells inflammation platelets thrombo‐inflammation thrombosis Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	immune cells inflammation platelets thrombo‐inflammation thrombosis Diseases of the blood and blood-forming organs RC633-647.5 Julie Rayes Joshua H. Bourne Alexander Brill Steve P. Watson The dual role of platelet‐innate immune cell interactions in thrombo‐inflammation
description	Abstract Beyond their role in hemostasis and thrombosis, platelets are increasingly recognized as key regulators of the inflammatory response under sterile and infectious conditions. Both platelet receptors and secretion are critical for these functions and contribute to their interaction with the endothelium and innate immune system. Platelet‐leukocyte interactions are increased in thrombo‐inflammatory diseases and are sensitive biomarkers for platelet activation and targets for the development of new therapies. The crosstalk between platelets and innate immune cells promotes thrombosis, inflammation, and tissue damage. However, recent studies have shown that these interactions also regulate the resolution of inflammation, tissue repair, and wound healing. Many of the platelet and leukocyte receptors involved in these bidirectional interactions are not selective for a subset of immune cells. However, specific heterotypic interactions occur in different vascular beds and inflammatory conditions, raising the possibility of disease‐ and organ‐specific pathways of intervention. In this review, we highlight and discuss prominent and emerging interrelationships between platelets and innate immune cells and their dual role in the regulation of the inflammatory response in sterile and infectious thrombo‐inflammatory diseases. A better understanding of the functional relevance of these interactions in different vascular beds may provide opportunities for successful therapeutic interventions to regulate the development, progression, and chronicity of various pathological processes.
format	article
author	Julie Rayes Joshua H. Bourne Alexander Brill Steve P. Watson
author_facet	Julie Rayes Joshua H. Bourne Alexander Brill Steve P. Watson
author_sort	Julie Rayes
title	The dual role of platelet‐innate immune cell interactions in thrombo‐inflammation
title_short	The dual role of platelet‐innate immune cell interactions in thrombo‐inflammation
title_full	The dual role of platelet‐innate immune cell interactions in thrombo‐inflammation
title_fullStr	The dual role of platelet‐innate immune cell interactions in thrombo‐inflammation
title_full_unstemmed	The dual role of platelet‐innate immune cell interactions in thrombo‐inflammation
title_sort	dual role of platelet‐innate immune cell interactions in thrombo‐inflammation
publisher	Wiley
publishDate	2020
url	https://doaj.org/article/c7ec012f308a4eb1861951ab4c9a7ff8
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The dual role of platelet‐innate immune cell interactions in thrombo‐inflammation

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