KRAS drives immune evasion in a genetic model of pancreatic cancer

Oncogenic KRAS signalling is required for tumor initiation; however KRAS-dependency at advanced stages is less understood. Here, the authors show that, in established KRAS-driven pancreatic cancer, KRAS-ablation does not affect intrinsic tumorigenic capacity but elicits antitumor immune response, hi...

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Autores principales:	Irene Ischenko, Stephen D’Amico, Manisha Rao, Jinyu Li, Michael J. Hayman, Scott Powers, Oleksi Petrenko, Nancy C. Reich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c7ec33167ea44efca36a6b1671871b0e
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spelling	oai:doaj.org-article:c7ec33167ea44efca36a6b1671871b0e2021-12-02T15:53:26ZKRAS drives immune evasion in a genetic model of pancreatic cancer10.1038/s41467-021-21736-w2041-1723https://doaj.org/article/c7ec33167ea44efca36a6b1671871b0e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21736-whttps://doaj.org/toc/2041-1723Oncogenic KRAS signalling is required for tumor initiation; however KRAS-dependency at advanced stages is less understood. Here, the authors show that, in established KRAS-driven pancreatic cancer, KRAS-ablation does not affect intrinsic tumorigenic capacity but elicits antitumor immune response, highlighting the importance of KRAS-driven immune suppression in tumor maintenance.Irene IschenkoStephen D’AmicoManisha RaoJinyu LiMichael J. HaymanScott PowersOleksi PetrenkoNancy C. ReichNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Irene Ischenko Stephen D’Amico Manisha Rao Jinyu Li Michael J. Hayman Scott Powers Oleksi Petrenko Nancy C. Reich KRAS drives immune evasion in a genetic model of pancreatic cancer
description	Oncogenic KRAS signalling is required for tumor initiation; however KRAS-dependency at advanced stages is less understood. Here, the authors show that, in established KRAS-driven pancreatic cancer, KRAS-ablation does not affect intrinsic tumorigenic capacity but elicits antitumor immune response, highlighting the importance of KRAS-driven immune suppression in tumor maintenance.
format	article
author	Irene Ischenko Stephen D’Amico Manisha Rao Jinyu Li Michael J. Hayman Scott Powers Oleksi Petrenko Nancy C. Reich
author_facet	Irene Ischenko Stephen D’Amico Manisha Rao Jinyu Li Michael J. Hayman Scott Powers Oleksi Petrenko Nancy C. Reich
author_sort	Irene Ischenko
title	KRAS drives immune evasion in a genetic model of pancreatic cancer
title_short	KRAS drives immune evasion in a genetic model of pancreatic cancer
title_full	KRAS drives immune evasion in a genetic model of pancreatic cancer
title_fullStr	KRAS drives immune evasion in a genetic model of pancreatic cancer
title_full_unstemmed	KRAS drives immune evasion in a genetic model of pancreatic cancer
title_sort	kras drives immune evasion in a genetic model of pancreatic cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c7ec33167ea44efca36a6b1671871b0e
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KRAS drives immune evasion in a genetic model of pancreatic cancer

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