KRAS drives immune evasion in a genetic model of pancreatic cancer

KRAS drives immune evasion in a genetic model of pancreatic cancer

Oncogenic KRAS signalling is required for tumor initiation; however KRAS-dependency at advanced stages is less understood. Here, the authors show that, in established KRAS-driven pancreatic cancer, KRAS-ablation does not affect intrinsic tumorigenic capacity but elicits antitumor immune response, hi...

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Autores principales: Irene Ischenko, Stephen D’Amico, Manisha Rao, Jinyu Li, Michael J. Hayman, Scott Powers, Oleksi Petrenko, Nancy C. Reich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/c7ec33167ea44efca36a6b1671871b0e
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