Sensors for the detection of ammonia as a potential biomarker for health screening

Abstract The presence of ammonia within the body has long been linked to complications stemming from the liver, kidneys, and stomach. These complications can be the result of serious conditions such as chronic kidney disease (CKD), peptic ulcers, and recently COVID-19. Limited liver and kidney funct...

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Autores principales:	Peter P. Ricci, Otto J. Gregory
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7ee20f70a0e4db8bea92f463fd6ab5d
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spelling	oai:doaj.org-article:c7ee20f70a0e4db8bea92f463fd6ab5d2021-12-02T14:23:04ZSensors for the detection of ammonia as a potential biomarker for health screening10.1038/s41598-021-86686-12045-2322https://doaj.org/article/c7ee20f70a0e4db8bea92f463fd6ab5d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86686-1https://doaj.org/toc/2045-2322Abstract The presence of ammonia within the body has long been linked to complications stemming from the liver, kidneys, and stomach. These complications can be the result of serious conditions such as chronic kidney disease (CKD), peptic ulcers, and recently COVID-19. Limited liver and kidney function leads to increased blood urea nitrogen (BUN) within the body resulting in elevated levels of ammonia in the mouth, nose, and skin. Similarly, peptic ulcers, commonly from H. pylori, result in ammonia production from urea within the stomach. The presence of these biomarkers enables a potential screening protocol to be considered for frequent, non-invasive monitoring of these conditions. Unfortunately, detection of ammonia in these mediums is rather challenging due to relatively small concentrations and an abundance of interferents. Currently, there are no options available for non-invasive screening of these conditions continuously and in real-time. Here we demonstrate the selective detection of ammonia using a vapor phase thermodynamic sensing platform capable of being employed as part of a health screening protocol. The results show that our detection system has the remarkable ability to selectively detect trace levels of ammonia in the vapor phase using a single catalyst. Additionally, detection was demonstrated in the presence of interferents such as carbon dioxide (CO2) and acetone common in human breath. These results show that our thermodynamic sensors are well suited to selectively detect ammonia at levels that could potentially be useful for health screening applications.Peter P. RicciOtto J. GregoryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter P. Ricci Otto J. Gregory Sensors for the detection of ammonia as a potential biomarker for health screening
description	Abstract The presence of ammonia within the body has long been linked to complications stemming from the liver, kidneys, and stomach. These complications can be the result of serious conditions such as chronic kidney disease (CKD), peptic ulcers, and recently COVID-19. Limited liver and kidney function leads to increased blood urea nitrogen (BUN) within the body resulting in elevated levels of ammonia in the mouth, nose, and skin. Similarly, peptic ulcers, commonly from H. pylori, result in ammonia production from urea within the stomach. The presence of these biomarkers enables a potential screening protocol to be considered for frequent, non-invasive monitoring of these conditions. Unfortunately, detection of ammonia in these mediums is rather challenging due to relatively small concentrations and an abundance of interferents. Currently, there are no options available for non-invasive screening of these conditions continuously and in real-time. Here we demonstrate the selective detection of ammonia using a vapor phase thermodynamic sensing platform capable of being employed as part of a health screening protocol. The results show that our detection system has the remarkable ability to selectively detect trace levels of ammonia in the vapor phase using a single catalyst. Additionally, detection was demonstrated in the presence of interferents such as carbon dioxide (CO2) and acetone common in human breath. These results show that our thermodynamic sensors are well suited to selectively detect ammonia at levels that could potentially be useful for health screening applications.
format	article
author	Peter P. Ricci Otto J. Gregory
author_facet	Peter P. Ricci Otto J. Gregory
author_sort	Peter P. Ricci
title	Sensors for the detection of ammonia as a potential biomarker for health screening
title_short	Sensors for the detection of ammonia as a potential biomarker for health screening
title_full	Sensors for the detection of ammonia as a potential biomarker for health screening
title_fullStr	Sensors for the detection of ammonia as a potential biomarker for health screening
title_full_unstemmed	Sensors for the detection of ammonia as a potential biomarker for health screening
title_sort	sensors for the detection of ammonia as a potential biomarker for health screening
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c7ee20f70a0e4db8bea92f463fd6ab5d
work_keys_str_mv	AT peterpricci sensorsforthedetectionofammoniaasapotentialbiomarkerforhealthscreening AT ottojgregory sensorsforthedetectionofammoniaasapotentialbiomarkerforhealthscreening
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Sensors for the detection of ammonia as a potential biomarker for health screening

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