Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer

Abstract Progesterone soft capsules (brand name: Utrogestan) were demonstrated to be an effective oral alternative to prevent premature LH surges both in normal-ovulatory and polycystic ovarian syndrome (PCOS) patients. However, its safety in terms of neonatal outcomes is unclear. To evaluate whethe...

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Autores principales:	Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7f1a0bcd73e496d996b13c6bb376999
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spelling	oai:doaj.org-article:c7f1a0bcd73e496d996b13c6bb3769992021-12-02T15:06:04ZComparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer10.1038/s41598-017-08472-22045-2322https://doaj.org/article/c7f1a0bcd73e496d996b13c6bb3769992017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08472-2https://doaj.org/toc/2045-2322Abstract Progesterone soft capsules (brand name: Utrogestan) were demonstrated to be an effective oral alternative to prevent premature LH surges both in normal-ovulatory and polycystic ovarian syndrome (PCOS) patients. However, its safety in terms of neonatal outcomes is unclear. To evaluate whether Utrogestan use increase the risk of adverse neonatal outcomes compared with short protocol in patients undergoing IVF/ICSI treatments in combination with frozen-thawed embryo transfer (FET), we performed a retrospective analysis including 1008 FET cycles, with embryos originated from either Utrogestan + hMG protocol (n = 499), or short protocol (n = 509), which led to 546 live-born infants. The neonatal characteristics regarding preterm birth (PTB), low birth weight (LBW), gestational age and mode of delivery were comparable in the two groups. The incidence of live-birth defect was 0.68% (2/293) in the Utrogestan + hMG protocol compared with 0.79% (2/253) in the short protocol. No early neonatal death or intrauterine death were recorded in either group. To date, the data do not indicate an elevated rate of abnormality at birth after progesterone use during ovarian stimulation but further study with larger populations is needed to confirm these results.Xiuxian ZhuHongjuan YeYonglun FuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiuxian Zhu Hongjuan Ye Yonglun Fu Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer
description	Abstract Progesterone soft capsules (brand name: Utrogestan) were demonstrated to be an effective oral alternative to prevent premature LH surges both in normal-ovulatory and polycystic ovarian syndrome (PCOS) patients. However, its safety in terms of neonatal outcomes is unclear. To evaluate whether Utrogestan use increase the risk of adverse neonatal outcomes compared with short protocol in patients undergoing IVF/ICSI treatments in combination with frozen-thawed embryo transfer (FET), we performed a retrospective analysis including 1008 FET cycles, with embryos originated from either Utrogestan + hMG protocol (n = 499), or short protocol (n = 509), which led to 546 live-born infants. The neonatal characteristics regarding preterm birth (PTB), low birth weight (LBW), gestational age and mode of delivery were comparable in the two groups. The incidence of live-birth defect was 0.68% (2/293) in the Utrogestan + hMG protocol compared with 0.79% (2/253) in the short protocol. No early neonatal death or intrauterine death were recorded in either group. To date, the data do not indicate an elevated rate of abnormality at birth after progesterone use during ovarian stimulation but further study with larger populations is needed to confirm these results.
format	article
author	Xiuxian Zhu Hongjuan Ye Yonglun Fu
author_facet	Xiuxian Zhu Hongjuan Ye Yonglun Fu
author_sort	Xiuxian Zhu
title	Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer
title_short	Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer
title_full	Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer
title_fullStr	Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer
title_full_unstemmed	Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer
title_sort	comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c7f1a0bcd73e496d996b13c6bb376999
work_keys_str_mv	AT xiuxianzhu comparisonofneonataloutcomesfollowingprogesteroneuseduringovarianstimulationwithfrozenthawedembryotransfer AT hongjuanye comparisonofneonataloutcomesfollowingprogesteroneuseduringovarianstimulationwithfrozenthawedembryotransfer AT yonglunfu comparisonofneonataloutcomesfollowingprogesteroneuseduringovarianstimulationwithfrozenthawedembryotransfer
_version_	1718388609577385984

Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer

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