Associations between serum homocysteine levels and anxiety and depression among children and adolescents in Taiwan

Abstract Although evidence suggests that homocysteine levels are elevated in severe mental illness in children, findings regarding homocysteine levels in youth with anxiety and depression are scarce. Therefore, this study examined the association of homocysteine levels with anxiety and depression in...

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Autores principales:	Kuo-Hsuan Chung, Hung-Yi Chiou, Yi-Hua Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7f4663e38f0414a967904b2504a2486
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spelling	oai:doaj.org-article:c7f4663e38f0414a967904b2504a24862021-12-02T16:06:48ZAssociations between serum homocysteine levels and anxiety and depression among children and adolescents in Taiwan10.1038/s41598-017-08568-92045-2322https://doaj.org/article/c7f4663e38f0414a967904b2504a24862017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08568-9https://doaj.org/toc/2045-2322Abstract Although evidence suggests that homocysteine levels are elevated in severe mental illness in children, findings regarding homocysteine levels in youth with anxiety and depression are scarce. Therefore, this study examined the association of homocysteine levels with anxiety and depression in a community sample of students aged 6–13 years. In total, 649 students were selected from the first, fourth, and seventh grades of schools in Taipei, Taiwan, in 2010. These students completed a hospital-based health examination, which included physical examination, blood sample collection, and questionnaire administration. The data were analysed through multiple linear regression. Among the seventh-grade boys, both depression (adjusted β = 0.044, 95% confidence interval (CI) = 0.004–0.084) and anxiety (adjusted β = 0.052, 95% CI = 0.013–0.091) were independently associated with increased homocysteine levels. In further dichotomisation, compared with students with low anxiety levels, those with moderate to high anxiety levels were significantly positively associated with elevated serum homocysteine levels (adjusted β = 0.091, 95% CI = 0.003–0.180). Our results suggest that increased depression and anxiety may be positively associated with higher serum homocysteine levels in older boys. Our results provide essential data on the biological aspects underlying anxiety and depression in the studied population.Kuo-Hsuan ChungHung-Yi ChiouYi-Hua ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kuo-Hsuan Chung Hung-Yi Chiou Yi-Hua Chen Associations between serum homocysteine levels and anxiety and depression among children and adolescents in Taiwan
description	Abstract Although evidence suggests that homocysteine levels are elevated in severe mental illness in children, findings regarding homocysteine levels in youth with anxiety and depression are scarce. Therefore, this study examined the association of homocysteine levels with anxiety and depression in a community sample of students aged 6–13 years. In total, 649 students were selected from the first, fourth, and seventh grades of schools in Taipei, Taiwan, in 2010. These students completed a hospital-based health examination, which included physical examination, blood sample collection, and questionnaire administration. The data were analysed through multiple linear regression. Among the seventh-grade boys, both depression (adjusted β = 0.044, 95% confidence interval (CI) = 0.004–0.084) and anxiety (adjusted β = 0.052, 95% CI = 0.013–0.091) were independently associated with increased homocysteine levels. In further dichotomisation, compared with students with low anxiety levels, those with moderate to high anxiety levels were significantly positively associated with elevated serum homocysteine levels (adjusted β = 0.091, 95% CI = 0.003–0.180). Our results suggest that increased depression and anxiety may be positively associated with higher serum homocysteine levels in older boys. Our results provide essential data on the biological aspects underlying anxiety and depression in the studied population.
format	article
author	Kuo-Hsuan Chung Hung-Yi Chiou Yi-Hua Chen
author_facet	Kuo-Hsuan Chung Hung-Yi Chiou Yi-Hua Chen
author_sort	Kuo-Hsuan Chung
title	Associations between serum homocysteine levels and anxiety and depression among children and adolescents in Taiwan
title_short	Associations between serum homocysteine levels and anxiety and depression among children and adolescents in Taiwan
title_full	Associations between serum homocysteine levels and anxiety and depression among children and adolescents in Taiwan
title_fullStr	Associations between serum homocysteine levels and anxiety and depression among children and adolescents in Taiwan
title_full_unstemmed	Associations between serum homocysteine levels and anxiety and depression among children and adolescents in Taiwan
title_sort	associations between serum homocysteine levels and anxiety and depression among children and adolescents in taiwan
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c7f4663e38f0414a967904b2504a2486
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Associations between serum homocysteine levels and anxiety and depression among children and adolescents in Taiwan

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