Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly

The clinical potential of peptide therapeutic agents can only be fully realised once their physicochemical and pharmacokinetic properties are precisely controlled. Here the authors show a reversible peptide self-assembly strategy to control and prolong the bioactivity of a native peptide hormone in...

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Autores principales:	Myriam M. Ouberai, Ana L. Gomes Dos Santos, Sonja Kinna, Shimona Madalli, David C. Hornigold, David Baker, Jacqueline Naylor, Laura Sheldrake, Dominic J. Corkill, John Hood, Paolo Vicini, Shahid Uddin, Steven Bishop, Paul G. Varley, Mark E. Welland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c7f770bfea9c44cf8e0311310d874e5d
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spelling	oai:doaj.org-article:c7f770bfea9c44cf8e0311310d874e5d2021-12-02T17:06:24ZControlling the bioactivity of a peptide hormone in vivo by reversible self-assembly10.1038/s41467-017-01114-12041-1723https://doaj.org/article/c7f770bfea9c44cf8e0311310d874e5d2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01114-1https://doaj.org/toc/2041-1723The clinical potential of peptide therapeutic agents can only be fully realised once their physicochemical and pharmacokinetic properties are precisely controlled. Here the authors show a reversible peptide self-assembly strategy to control and prolong the bioactivity of a native peptide hormone in vivo.Myriam M. OuberaiAna L. Gomes Dos SantosSonja KinnaShimona MadalliDavid C. HornigoldDavid BakerJacqueline NaylorLaura SheldrakeDominic J. CorkillJohn HoodPaolo ViciniShahid UddinSteven BishopPaul G. VarleyMark E. WellandNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Myriam M. Ouberai Ana L. Gomes Dos Santos Sonja Kinna Shimona Madalli David C. Hornigold David Baker Jacqueline Naylor Laura Sheldrake Dominic J. Corkill John Hood Paolo Vicini Shahid Uddin Steven Bishop Paul G. Varley Mark E. Welland Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly
description	The clinical potential of peptide therapeutic agents can only be fully realised once their physicochemical and pharmacokinetic properties are precisely controlled. Here the authors show a reversible peptide self-assembly strategy to control and prolong the bioactivity of a native peptide hormone in vivo.
format	article
author	Myriam M. Ouberai Ana L. Gomes Dos Santos Sonja Kinna Shimona Madalli David C. Hornigold David Baker Jacqueline Naylor Laura Sheldrake Dominic J. Corkill John Hood Paolo Vicini Shahid Uddin Steven Bishop Paul G. Varley Mark E. Welland
author_facet	Myriam M. Ouberai Ana L. Gomes Dos Santos Sonja Kinna Shimona Madalli David C. Hornigold David Baker Jacqueline Naylor Laura Sheldrake Dominic J. Corkill John Hood Paolo Vicini Shahid Uddin Steven Bishop Paul G. Varley Mark E. Welland
author_sort	Myriam M. Ouberai
title	Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly
title_short	Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly
title_full	Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly
title_fullStr	Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly
title_full_unstemmed	Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly
title_sort	controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c7f770bfea9c44cf8e0311310d874e5d
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Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly

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