miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine

Homeostasis of the intestinal epithelium is crucial for the maintenance of the epithelial barrier. Here, the authors show that mir-802 ablation in the mouse intestine impairs enterocyte differentiation and glucose absorption, enhances Paneth cell function by increasing Tmed9-mediated defensin secret...

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Autores principales:	Algera Goga, Büsra Yagabasan, Karolin Herrmanns, Svenja Godbersen, Pamuditha N. Silva, Remy Denzler, Mirjam Zünd, Markus Furter, Gerald Schwank, Shinichi Sunagawa, Wolf-Dietrich Hardt, Markus Stoffel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c7f78656546746ebbee47397d3bee506
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spelling	oai:doaj.org-article:c7f78656546746ebbee47397d3bee5062021-12-02T17:52:38ZmiR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine10.1038/s41467-021-23298-32041-1723https://doaj.org/article/c7f78656546746ebbee47397d3bee5062021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23298-3https://doaj.org/toc/2041-1723Homeostasis of the intestinal epithelium is crucial for the maintenance of the epithelial barrier. Here, the authors show that mir-802 ablation in the mouse intestine impairs enterocyte differentiation and glucose absorption, enhances Paneth cell function by increasing Tmed9-mediated defensin secretion, and increases epithelial cell turnover.Algera GogaBüsra YagabasanKarolin HerrmannsSvenja GodbersenPamuditha N. SilvaRemy DenzlerMirjam ZündMarkus FurterGerald SchwankShinichi SunagawaWolf-Dietrich HardtMarkus StoffelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Algera Goga Büsra Yagabasan Karolin Herrmanns Svenja Godbersen Pamuditha N. Silva Remy Denzler Mirjam Zünd Markus Furter Gerald Schwank Shinichi Sunagawa Wolf-Dietrich Hardt Markus Stoffel miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine
description	Homeostasis of the intestinal epithelium is crucial for the maintenance of the epithelial barrier. Here, the authors show that mir-802 ablation in the mouse intestine impairs enterocyte differentiation and glucose absorption, enhances Paneth cell function by increasing Tmed9-mediated defensin secretion, and increases epithelial cell turnover.
format	article
author	Algera Goga Büsra Yagabasan Karolin Herrmanns Svenja Godbersen Pamuditha N. Silva Remy Denzler Mirjam Zünd Markus Furter Gerald Schwank Shinichi Sunagawa Wolf-Dietrich Hardt Markus Stoffel
author_facet	Algera Goga Büsra Yagabasan Karolin Herrmanns Svenja Godbersen Pamuditha N. Silva Remy Denzler Mirjam Zünd Markus Furter Gerald Schwank Shinichi Sunagawa Wolf-Dietrich Hardt Markus Stoffel
author_sort	Algera Goga
title	miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine
title_short	miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine
title_full	miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine
title_fullStr	miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine
title_full_unstemmed	miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine
title_sort	mir-802 regulates paneth cell function and enterocyte differentiation in the mouse small intestine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c7f78656546746ebbee47397d3bee506
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miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine

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