Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus Daphne

There are abundant natural diterpenoids in the plants of the genus Daphne from the Thymelaeaceae family, featuring a 5/7/6-tricyclic ring system and usually with an orthoester group. So far, a total of 135 diterpenoids has been isolated from the species of the genus Daphn...

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Autores principales:	Yi-Wen Nie, Yuan Li, Lan Luo, Chun-Yan Zhang, Wei Fan, Wei-Ying Gu, Kou-Rong Shi, Xiao-Xiang Zhai, Jian-Yong Zhu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Daphne</i> diterpenoid bioactivities Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/c7f7ed9052fe45559f041404bb4391c3
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spelling	oai:doaj.org-article:c7f7ed9052fe45559f041404bb4391c32021-11-11T18:34:25ZPhytochemistry and Pharmacological Activities of the Diterpenoids from the Genus <i>Daphne</i>10.3390/molecules262165981420-3049https://doaj.org/article/c7f7ed9052fe45559f041404bb4391c32021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6598https://doaj.org/toc/1420-3049There are abundant natural diterpenoids in the plants of the genus <i>Daphne</i> from the Thymelaeaceae family, featuring a 5/7/6-tricyclic ring system and usually with an orthoester group. So far, a total of 135 diterpenoids has been isolated from the species of the genus <i>Daphne</i>, which could be further classified into three main types according to the substitution pattern of ring A and oxygen-containing functions at ring B. A variety of studies have demonstrated that these compounds exert a wide range of bioactivities both in vitro and in vivo including anticancer, anti-inflammatory, anti-HIV, antifertility, neurotrophic, and cholesterol-lowering effects, which is reviewed herein. Meanwhile, the fascinating structure–activity relationship is also concluded in this review in the hope of providing an easy access to available information for the synthesis and optimization of efficient drugs.Yi-Wen NieYuan LiLan LuoChun-Yan ZhangWei FanWei-Ying GuKou-Rong ShiXiao-Xiang ZhaiJian-Yong ZhuMDPI AGarticle<i>Daphne</i>diterpenoidbioactivitiesOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6598, p 6598 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Daphne</i> diterpenoid bioactivities Organic chemistry QD241-441
spellingShingle	<i>Daphne</i> diterpenoid bioactivities Organic chemistry QD241-441 Yi-Wen Nie Yuan Li Lan Luo Chun-Yan Zhang Wei Fan Wei-Ying Gu Kou-Rong Shi Xiao-Xiang Zhai Jian-Yong Zhu Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus <i>Daphne</i>
description	There are abundant natural diterpenoids in the plants of the genus <i>Daphne</i> from the Thymelaeaceae family, featuring a 5/7/6-tricyclic ring system and usually with an orthoester group. So far, a total of 135 diterpenoids has been isolated from the species of the genus <i>Daphne</i>, which could be further classified into three main types according to the substitution pattern of ring A and oxygen-containing functions at ring B. A variety of studies have demonstrated that these compounds exert a wide range of bioactivities both in vitro and in vivo including anticancer, anti-inflammatory, anti-HIV, antifertility, neurotrophic, and cholesterol-lowering effects, which is reviewed herein. Meanwhile, the fascinating structure–activity relationship is also concluded in this review in the hope of providing an easy access to available information for the synthesis and optimization of efficient drugs.
format	article
author	Yi-Wen Nie Yuan Li Lan Luo Chun-Yan Zhang Wei Fan Wei-Ying Gu Kou-Rong Shi Xiao-Xiang Zhai Jian-Yong Zhu
author_facet	Yi-Wen Nie Yuan Li Lan Luo Chun-Yan Zhang Wei Fan Wei-Ying Gu Kou-Rong Shi Xiao-Xiang Zhai Jian-Yong Zhu
author_sort	Yi-Wen Nie
title	Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus <i>Daphne</i>
title_short	Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus <i>Daphne</i>
title_full	Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus <i>Daphne</i>
title_fullStr	Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus <i>Daphne</i>
title_full_unstemmed	Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus <i>Daphne</i>
title_sort	phytochemistry and pharmacological activities of the diterpenoids from the genus <i>daphne</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c7f7ed9052fe45559f041404bb4391c3
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Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus <i>Daphne</i>

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