General psychopathology links burden of recent life events and psychotic symptoms in a network approach

Abstract Recent life events have been implicated in the onset and progression of psychosis. However, psychological processes that account for the association are yet to be fully understood. Using a network approach, we aimed to identify pathways linking recent life events and symptoms observed in ps...

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Autores principales:	Linda T. Betz, Nora Penzel, Lana Kambeitz-Ilankovic, Marlene Rosen, Katharine Chisholm, Alexandra Stainton, Theresa K. Haidl, Julian Wenzel, Alessandro Bertolino, Stefan Borgwardt, Paolo Brambilla, Rebekka Lencer, Eva Meisenzahl, Stephan Ruhrmann, Raimo K. R. Salokangas, Frauke Schultze-Lutter, Stephen J. Wood, Rachel Upthegrove, Nikolaos Koutsouleris, Joseph Kambeitz, the PRONIA consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/c7f860bdff444f89889c1753c4974c99
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spelling	oai:doaj.org-article:c7f860bdff444f89889c1753c4974c992021-12-02T13:33:28ZGeneral psychopathology links burden of recent life events and psychotic symptoms in a network approach10.1038/s41537-020-00129-w2334-265Xhttps://doaj.org/article/c7f860bdff444f89889c1753c4974c992020-12-01T00:00:00Zhttps://doi.org/10.1038/s41537-020-00129-whttps://doaj.org/toc/2334-265XAbstract Recent life events have been implicated in the onset and progression of psychosis. However, psychological processes that account for the association are yet to be fully understood. Using a network approach, we aimed to identify pathways linking recent life events and symptoms observed in psychosis. Based on previous literature, we hypothesized that general symptoms would mediate between recent life events and psychotic symptoms. We analyzed baseline data of patients at clinical high risk for psychosis and with recent-onset psychosis (n = 547) from the Personalised Prognostic Tools for Early Psychosis Management (PRONIA) study. In a network analysis, we modeled links between the burden of recent life events and all individual symptoms of the Positive and Negative Syndrome Scale before and after controlling for childhood trauma. To investigate the longitudinal associations between burden of recent life events and symptoms, we analyzed multiwave panel data from seven timepoints up to month 18. Corroborating our hypothesis, burden of recent life events was connected to positive and negative symptoms through general psychopathology, specifically depression, guilt feelings, anxiety and tension, even after controlling for childhood trauma. Longitudinal modeling indicated that on average, burden of recent life events preceded general psychopathology in the individual. In line with the theory of an affective pathway to psychosis, recent life events may lead to psychotic symptoms via heightened emotional distress. Life events may be one driving force of unspecific, general psychopathology described as characteristic of early phases of the psychosis spectrum, offering promising avenues for interventions.Linda T. BetzNora PenzelLana Kambeitz-IlankovicMarlene RosenKatharine ChisholmAlexandra StaintonTheresa K. HaidlJulian WenzelAlessandro BertolinoStefan BorgwardtPaolo BrambillaRebekka LencerEva MeisenzahlStephan RuhrmannRaimo K. R. SalokangasFrauke Schultze-LutterStephen J. WoodRachel UpthegroveNikolaos KoutsoulerisJoseph Kambeitzthe PRONIA consortiumNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 6, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Linda T. Betz Nora Penzel Lana Kambeitz-Ilankovic Marlene Rosen Katharine Chisholm Alexandra Stainton Theresa K. Haidl Julian Wenzel Alessandro Bertolino Stefan Borgwardt Paolo Brambilla Rebekka Lencer Eva Meisenzahl Stephan Ruhrmann Raimo K. R. Salokangas Frauke Schultze-Lutter Stephen J. Wood Rachel Upthegrove Nikolaos Koutsouleris Joseph Kambeitz the PRONIA consortium General psychopathology links burden of recent life events and psychotic symptoms in a network approach
description	Abstract Recent life events have been implicated in the onset and progression of psychosis. However, psychological processes that account for the association are yet to be fully understood. Using a network approach, we aimed to identify pathways linking recent life events and symptoms observed in psychosis. Based on previous literature, we hypothesized that general symptoms would mediate between recent life events and psychotic symptoms. We analyzed baseline data of patients at clinical high risk for psychosis and with recent-onset psychosis (n = 547) from the Personalised Prognostic Tools for Early Psychosis Management (PRONIA) study. In a network analysis, we modeled links between the burden of recent life events and all individual symptoms of the Positive and Negative Syndrome Scale before and after controlling for childhood trauma. To investigate the longitudinal associations between burden of recent life events and symptoms, we analyzed multiwave panel data from seven timepoints up to month 18. Corroborating our hypothesis, burden of recent life events was connected to positive and negative symptoms through general psychopathology, specifically depression, guilt feelings, anxiety and tension, even after controlling for childhood trauma. Longitudinal modeling indicated that on average, burden of recent life events preceded general psychopathology in the individual. In line with the theory of an affective pathway to psychosis, recent life events may lead to psychotic symptoms via heightened emotional distress. Life events may be one driving force of unspecific, general psychopathology described as characteristic of early phases of the psychosis spectrum, offering promising avenues for interventions.
format	article
author	Linda T. Betz Nora Penzel Lana Kambeitz-Ilankovic Marlene Rosen Katharine Chisholm Alexandra Stainton Theresa K. Haidl Julian Wenzel Alessandro Bertolino Stefan Borgwardt Paolo Brambilla Rebekka Lencer Eva Meisenzahl Stephan Ruhrmann Raimo K. R. Salokangas Frauke Schultze-Lutter Stephen J. Wood Rachel Upthegrove Nikolaos Koutsouleris Joseph Kambeitz the PRONIA consortium
author_facet	Linda T. Betz Nora Penzel Lana Kambeitz-Ilankovic Marlene Rosen Katharine Chisholm Alexandra Stainton Theresa K. Haidl Julian Wenzel Alessandro Bertolino Stefan Borgwardt Paolo Brambilla Rebekka Lencer Eva Meisenzahl Stephan Ruhrmann Raimo K. R. Salokangas Frauke Schultze-Lutter Stephen J. Wood Rachel Upthegrove Nikolaos Koutsouleris Joseph Kambeitz the PRONIA consortium
author_sort	Linda T. Betz
title	General psychopathology links burden of recent life events and psychotic symptoms in a network approach
title_short	General psychopathology links burden of recent life events and psychotic symptoms in a network approach
title_full	General psychopathology links burden of recent life events and psychotic symptoms in a network approach
title_fullStr	General psychopathology links burden of recent life events and psychotic symptoms in a network approach
title_full_unstemmed	General psychopathology links burden of recent life events and psychotic symptoms in a network approach
title_sort	general psychopathology links burden of recent life events and psychotic symptoms in a network approach
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c7f860bdff444f89889c1753c4974c99
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General psychopathology links burden of recent life events and psychotic symptoms in a network approach

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