Peculiarities of distribution of HLA class I antigens in patients with lihen planus

The article presents data on the distribution characteristics of the HLA class I system antigens in patients with lichen planus. Aim. To study the patterns of distribution of HLA class I antigens in the general group. To establish the presence of an association of the disease with antigens of the...

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Autores principales:	Irina I. Zakhur, Sergei V. Koshkin, Galina A. Zaitseva, Varvara A. Bobro
Formato:	article
Lenguaje:	RU
Publicado:	State Scientific Center of Dermatovenereology and Cosmetology 2021
Materias:	lichen planus immunogenetic indicators antigens of the hla complex Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/c7f8adf9de2c4039a3743b1156116bda
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spelling	oai:doaj.org-article:c7f8adf9de2c4039a3743b1156116bda2021-12-01T22:16:29ZPeculiarities of distribution of HLA class I antigens in patients with lihen planus0042-46092313-629410.25208/vdv1151https://doaj.org/article/c7f8adf9de2c4039a3743b1156116bda2021-03-01T00:00:00Zhttps://vestnikdv.ru/jour/article/viewFile/1151/1163https://doaj.org/toc/0042-4609https://doaj.org/toc/2313-6294The article presents data on the distribution characteristics of the HLA class I system antigens in patients with lichen planus. Aim. To study the patterns of distribution of HLA class I antigens in the general group. To establish the presence of an association of the disease with antigens of the HLA class I. Material and methods. Laboratory analysis of the distribution of HLA class I antigens was carried out in 60 patients with various forms of lichen planus who consider themselves Russian on the basis of linguistic and ethnicity. The duration of the disease is 120 years. Results. When analyzing the typing results in the general group of patients; a tendency to negative association of HLA-A11 and HLA-B7. It was found that the frequency of haplotype combinations A1-B8; A2-B27; A2-B40; A3-B35 significantly exceeded that of healthy people. Analysis of the frequency of phenotypic combinations revealed a significant increase in A3-A19 and B12-B35. Conclusion. Haplotype and phenotypic combinations of HLA A1-B8; A2-B27; A2-B40; A3-B35; A3-A19; B12-B35 are provoking factors in the development of various forms of the disease. The presence of these genetic traits in the individual increases the risk of developing lichen planus by 311 times. In turn; the HLA-A11 and B7 antigens play a protective role.Irina I. ZakhurSergei V. KoshkinGalina A. ZaitsevaVarvara A. BobroState Scientific Center of Dermatovenereology and Cosmetologyarticlelichen planusimmunogenetic indicatorsantigens of the hla complexDermatologyRL1-803RUVestnik Dermatologii i Venerologii, Vol 97, Iss 1, Pp 27-33 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	lichen planus immunogenetic indicators antigens of the hla complex Dermatology RL1-803
spellingShingle	lichen planus immunogenetic indicators antigens of the hla complex Dermatology RL1-803 Irina I. Zakhur Sergei V. Koshkin Galina A. Zaitseva Varvara A. Bobro Peculiarities of distribution of HLA class I antigens in patients with lihen planus
description	The article presents data on the distribution characteristics of the HLA class I system antigens in patients with lichen planus. Aim. To study the patterns of distribution of HLA class I antigens in the general group. To establish the presence of an association of the disease with antigens of the HLA class I. Material and methods. Laboratory analysis of the distribution of HLA class I antigens was carried out in 60 patients with various forms of lichen planus who consider themselves Russian on the basis of linguistic and ethnicity. The duration of the disease is 120 years. Results. When analyzing the typing results in the general group of patients; a tendency to negative association of HLA-A11 and HLA-B7. It was found that the frequency of haplotype combinations A1-B8; A2-B27; A2-B40; A3-B35 significantly exceeded that of healthy people. Analysis of the frequency of phenotypic combinations revealed a significant increase in A3-A19 and B12-B35. Conclusion. Haplotype and phenotypic combinations of HLA A1-B8; A2-B27; A2-B40; A3-B35; A3-A19; B12-B35 are provoking factors in the development of various forms of the disease. The presence of these genetic traits in the individual increases the risk of developing lichen planus by 311 times. In turn; the HLA-A11 and B7 antigens play a protective role.
format	article
author	Irina I. Zakhur Sergei V. Koshkin Galina A. Zaitseva Varvara A. Bobro
author_facet	Irina I. Zakhur Sergei V. Koshkin Galina A. Zaitseva Varvara A. Bobro
author_sort	Irina I. Zakhur
title	Peculiarities of distribution of HLA class I antigens in patients with lihen planus
title_short	Peculiarities of distribution of HLA class I antigens in patients with lihen planus
title_full	Peculiarities of distribution of HLA class I antigens in patients with lihen planus
title_fullStr	Peculiarities of distribution of HLA class I antigens in patients with lihen planus
title_full_unstemmed	Peculiarities of distribution of HLA class I antigens in patients with lihen planus
title_sort	peculiarities of distribution of hla class i antigens in patients with lihen planus
publisher	State Scientific Center of Dermatovenereology and Cosmetology
publishDate	2021
url	https://doaj.org/article/c7f8adf9de2c4039a3743b1156116bda
work_keys_str_mv	AT irinaizakhur peculiaritiesofdistributionofhlaclassiantigensinpatientswithlihenplanus AT sergeivkoshkin peculiaritiesofdistributionofhlaclassiantigensinpatientswithlihenplanus AT galinaazaitseva peculiaritiesofdistributionofhlaclassiantigensinpatientswithlihenplanus AT varvaraabobro peculiaritiesofdistributionofhlaclassiantigensinpatientswithlihenplanus
_version_	1718404187260190720

Peculiarities of distribution of HLA class I antigens in patients with lihen planus

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