Transmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis

Abstract Background This study aimed to investigate the transmission of cytomegalovirus (CMV) via breast milk in low birth weight (LBW) and premature infants and its effects. Methods PubMed, Medline, Cochrane Library, and Embase were searched for studies (without language and time restriction) publi...

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Autores principales:	Xiaolin Hu, Wei Hu, Xuan Sun, Ling Chen, Xiaoping Luo
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Breast milk Cytomegalovirus Preterm infant Infection transmission meta-analysis Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/c7fdc7428abd4bc094dc66d176b8925f
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spelling	oai:doaj.org-article:c7fdc7428abd4bc094dc66d176b8925f2021-11-28T12:30:14ZTransmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis10.1186/s12887-021-02984-71471-2431https://doaj.org/article/c7fdc7428abd4bc094dc66d176b8925f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-02984-7https://doaj.org/toc/1471-2431Abstract Background This study aimed to investigate the transmission of cytomegalovirus (CMV) via breast milk in low birth weight (LBW) and premature infants and its effects. Methods PubMed, Medline, Cochrane Library, and Embase were searched for studies (without language and time restriction) published before March 27, 2020, that examined the effect of CMV transmitted by breast milk on LBW and premature infants. The rates of breast milk-acquired CMV infection, CMV-related symptoms, and CMV-related sepsis-like syndrome (CMV-SLS) in LBW and premature infants were pooled from each study. Results Eighteen studies with 1920 LBW and premature infants were included. The pooled CMV infection rate from breast milk for infants fed untreated breast milk was significantly higher than those fed frozen breast milk [19.3, 95% confidence interval (CI) = 11.8–29.9% vs. 13.5, 95% CI = 8.0–22.0%, P < 0.01). Similarly, the pooled CMV infection rate for infants fed untreated breast milk was significantly higher than those with mixed feeding (P < 0.0001). The mixed feeding group had a significantly lower rate of CMV-related symptoms than the other groups (2.4%, P < 0.01). Conclusions These findings suggested a higher CMV infection rate in LBW or premature infants fed untreated breast milk than other feeding groups. Studies on the long-term outcomes of CMV infection transmitted from breast milk are needed to address the optimal feeding practice.Xiaolin HuWei HuXuan SunLing ChenXiaoping LuoBMCarticleBreast milkCytomegalovirusPreterm infantInfection transmissionmeta-analysisPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Breast milk Cytomegalovirus Preterm infant Infection transmission meta-analysis Pediatrics RJ1-570
spellingShingle	Breast milk Cytomegalovirus Preterm infant Infection transmission meta-analysis Pediatrics RJ1-570 Xiaolin Hu Wei Hu Xuan Sun Ling Chen Xiaoping Luo Transmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis
description	Abstract Background This study aimed to investigate the transmission of cytomegalovirus (CMV) via breast milk in low birth weight (LBW) and premature infants and its effects. Methods PubMed, Medline, Cochrane Library, and Embase were searched for studies (without language and time restriction) published before March 27, 2020, that examined the effect of CMV transmitted by breast milk on LBW and premature infants. The rates of breast milk-acquired CMV infection, CMV-related symptoms, and CMV-related sepsis-like syndrome (CMV-SLS) in LBW and premature infants were pooled from each study. Results Eighteen studies with 1920 LBW and premature infants were included. The pooled CMV infection rate from breast milk for infants fed untreated breast milk was significantly higher than those fed frozen breast milk [19.3, 95% confidence interval (CI) = 11.8–29.9% vs. 13.5, 95% CI = 8.0–22.0%, P < 0.01). Similarly, the pooled CMV infection rate for infants fed untreated breast milk was significantly higher than those with mixed feeding (P < 0.0001). The mixed feeding group had a significantly lower rate of CMV-related symptoms than the other groups (2.4%, P < 0.01). Conclusions These findings suggested a higher CMV infection rate in LBW or premature infants fed untreated breast milk than other feeding groups. Studies on the long-term outcomes of CMV infection transmitted from breast milk are needed to address the optimal feeding practice.
format	article
author	Xiaolin Hu Wei Hu Xuan Sun Ling Chen Xiaoping Luo
author_facet	Xiaolin Hu Wei Hu Xuan Sun Ling Chen Xiaoping Luo
author_sort	Xiaolin Hu
title	Transmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis
title_short	Transmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis
title_full	Transmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis
title_fullStr	Transmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis
title_full_unstemmed	Transmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis
title_sort	transmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c7fdc7428abd4bc094dc66d176b8925f
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Transmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis

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