Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states

Abstract Infraslow activity (ISA) and high-frequency activity (HFA) are key biomarkers for studying epileptic seizures. We aimed to elucidate the relationship between ISA and HFA around seizure onset. We enrolled seven patients with drug-resistant focal epilepsy who underwent intracranial electrode...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hiroaki Hashimoto, Hui Ming Khoo, Takufumi Yanagisawa, Naoki Tani, Satoru Oshino, Haruhiko Kishima, Masayuki Hirata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c7fffb77964649eda67cc544abb9dbc3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c7fffb77964649eda67cc544abb9dbc3
record_format	dspace
spelling	oai:doaj.org-article:c7fffb77964649eda67cc544abb9dbc32021-12-02T17:51:12ZPhase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states10.1038/s41598-021-96479-12045-2322https://doaj.org/article/c7fffb77964649eda67cc544abb9dbc32021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96479-1https://doaj.org/toc/2045-2322Abstract Infraslow activity (ISA) and high-frequency activity (HFA) are key biomarkers for studying epileptic seizures. We aimed to elucidate the relationship between ISA and HFA around seizure onset. We enrolled seven patients with drug-resistant focal epilepsy who underwent intracranial electrode placement. We comparatively analyzed the ISA, HFA, and ISA-HFA phase-amplitude coupling (PAC) in the seizure onset zone (SOZ) or non-SOZ (nSOZ) in the interictal, preictal, and ictal states. We recorded 15 seizures. HFA and ISA were larger in the ictal states than in the interictal or preictal state. During seizures, the HFA and ISA of the SOZ were larger and occurred earlier than those of nSOZ. In the preictal state, the ISA-HFA PAC of the SOZ was larger than that of the interictal state, and it began increasing at approximately 87 s before the seizure onset. The receiver-operating characteristic curve revealed that the ISA-HFA PAC of the SOZ showed the highest discrimination performance in the preictal and interictal states, with an area under the curve of 0.926. This study demonstrated the novel insight that ISA-HFA PAC increases before the onset of seizures. Our findings indicate that ISA-HFA PAC could be a useful biomarker for discriminating between the preictal and interictal states.Hiroaki HashimotoHui Ming KhooTakufumi YanagisawaNaoki TaniSatoru OshinoHaruhiko KishimaMasayuki HirataNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroaki Hashimoto Hui Ming Khoo Takufumi Yanagisawa Naoki Tani Satoru Oshino Haruhiko Kishima Masayuki Hirata Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states
description	Abstract Infraslow activity (ISA) and high-frequency activity (HFA) are key biomarkers for studying epileptic seizures. We aimed to elucidate the relationship between ISA and HFA around seizure onset. We enrolled seven patients with drug-resistant focal epilepsy who underwent intracranial electrode placement. We comparatively analyzed the ISA, HFA, and ISA-HFA phase-amplitude coupling (PAC) in the seizure onset zone (SOZ) or non-SOZ (nSOZ) in the interictal, preictal, and ictal states. We recorded 15 seizures. HFA and ISA were larger in the ictal states than in the interictal or preictal state. During seizures, the HFA and ISA of the SOZ were larger and occurred earlier than those of nSOZ. In the preictal state, the ISA-HFA PAC of the SOZ was larger than that of the interictal state, and it began increasing at approximately 87 s before the seizure onset. The receiver-operating characteristic curve revealed that the ISA-HFA PAC of the SOZ showed the highest discrimination performance in the preictal and interictal states, with an area under the curve of 0.926. This study demonstrated the novel insight that ISA-HFA PAC increases before the onset of seizures. Our findings indicate that ISA-HFA PAC could be a useful biomarker for discriminating between the preictal and interictal states.
format	article
author	Hiroaki Hashimoto Hui Ming Khoo Takufumi Yanagisawa Naoki Tani Satoru Oshino Haruhiko Kishima Masayuki Hirata
author_facet	Hiroaki Hashimoto Hui Ming Khoo Takufumi Yanagisawa Naoki Tani Satoru Oshino Haruhiko Kishima Masayuki Hirata
author_sort	Hiroaki Hashimoto
title	Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states
title_short	Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states
title_full	Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states
title_fullStr	Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states
title_full_unstemmed	Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states
title_sort	phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c7fffb77964649eda67cc544abb9dbc3
work_keys_str_mv	AT hiroakihashimoto phaseamplitudecouplingbetweeninfraslowandhighfrequencyactivitieswelldiscriminatesbetweenthepreictalandinterictalstates AT huimingkhoo phaseamplitudecouplingbetweeninfraslowandhighfrequencyactivitieswelldiscriminatesbetweenthepreictalandinterictalstates AT takufumiyanagisawa phaseamplitudecouplingbetweeninfraslowandhighfrequencyactivitieswelldiscriminatesbetweenthepreictalandinterictalstates AT naokitani phaseamplitudecouplingbetweeninfraslowandhighfrequencyactivitieswelldiscriminatesbetweenthepreictalandinterictalstates AT satoruoshino phaseamplitudecouplingbetweeninfraslowandhighfrequencyactivitieswelldiscriminatesbetweenthepreictalandinterictalstates AT haruhikokishima phaseamplitudecouplingbetweeninfraslowandhighfrequencyactivitieswelldiscriminatesbetweenthepreictalandinterictalstates AT masayukihirata phaseamplitudecouplingbetweeninfraslowandhighfrequencyactivitieswelldiscriminatesbetweenthepreictalandinterictalstates
_version_	1718379312783032320

Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states

Ejemplares similares