Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors

Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors

Cpf1 has been repurposed as a transcriptional repressor in bacteria and plants. Here, the authors construct activators and repressors in human cells using Cpf1 coupled to riboswitches and GPCRs.

Guardado en:
Detalles Bibliográficos
Autores principales: Yuchen Liu, Jinghong Han, Zhicong Chen, Hanwei Wu, Hongsong Dong, Guohui Nie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c8002b7c0f954b6b8839bea82b0d4ce3
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:c8002b7c0f954b6b8839bea82b0d4ce3
record_format dspace
spelling oai:doaj.org-article:c8002b7c0f954b6b8839bea82b0d4ce32021-12-02T17:06:15ZEngineering cell signaling using tunable CRISPR–Cpf1-based transcription factors10.1038/s41467-017-02265-x2041-1723https://doaj.org/article/c8002b7c0f954b6b8839bea82b0d4ce32017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02265-xhttps://doaj.org/toc/2041-1723Cpf1 has been repurposed as a transcriptional repressor in bacteria and plants. Here, the authors construct activators and repressors in human cells using Cpf1 coupled to riboswitches and GPCRs.Yuchen LiuJinghong HanZhicong ChenHanwei WuHongsong DongGuohui NieNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuchen Liu
Jinghong Han
Zhicong Chen
Hanwei Wu
Hongsong Dong
Guohui Nie
Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors
description Cpf1 has been repurposed as a transcriptional repressor in bacteria and plants. Here, the authors construct activators and repressors in human cells using Cpf1 coupled to riboswitches and GPCRs.
format article
author Yuchen Liu
Jinghong Han
Zhicong Chen
Hanwei Wu
Hongsong Dong
Guohui Nie
author_facet Yuchen Liu
Jinghong Han
Zhicong Chen
Hanwei Wu
Hongsong Dong
Guohui Nie
author_sort Yuchen Liu
title Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors
title_short Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors
title_full Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors
title_fullStr Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors
title_full_unstemmed Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors
title_sort engineering cell signaling using tunable crispr–cpf1-based transcription factors
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c8002b7c0f954b6b8839bea82b0d4ce3
work_keys_str_mv AT yuchenliu engineeringcellsignalingusingtunablecrisprcpf1basedtranscriptionfactors
AT jinghonghan engineeringcellsignalingusingtunablecrisprcpf1basedtranscriptionfactors
AT zhicongchen engineeringcellsignalingusingtunablecrisprcpf1basedtranscriptionfactors
AT hanweiwu engineeringcellsignalingusingtunablecrisprcpf1basedtranscriptionfactors
AT hongsongdong engineeringcellsignalingusingtunablecrisprcpf1basedtranscriptionfactors
AT guohuinie engineeringcellsignalingusingtunablecrisprcpf1basedtranscriptionfactors
_version_ 1718381698797797376

Ejemplares similares