Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes

Thanh Tung Tran Huu,1 Huu Dang Tran,2 Thua Nguyen Tran,3 Bui Bao Hoang2 1Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam; 2Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue City, Vietnam; 3Department of General Internal Medicine and Geriatrics,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tran Huu TT, Tran HD, Tran TN, Hoang BB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	vitamin d insulin resistance diabetes hba1c Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c800b2154ffa4b55ae30983138a7cba4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c800b2154ffa4b55ae30983138a7cba4
record_format	dspace
spelling	oai:doaj.org-article:c800b2154ffa4b55ae30983138a7cba42021-12-02T18:05:05ZRelationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes1178-7007https://doaj.org/article/c800b2154ffa4b55ae30983138a7cba42021-06-01T00:00:00Zhttps://www.dovepress.com/relationship-between-vitamin-d-status-and-the-relevant-parameters-of-g-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Thanh Tung Tran Huu,1 Huu Dang Tran,2 Thua Nguyen Tran,3 Bui Bao Hoang2 1Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam; 2Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue City, Vietnam; 3Department of General Internal Medicine and Geriatrics, Hue Central Hospital, Hue City, VietnamCorrespondence: Thua Nguyen TranDepartment of General Internal Medicine and Geriatrics, Hue Central Hospital, Hue City, VietnamTel +84903597695Email tranthuanguyen23@gmail.comIntroduction: Clarifying the prevalence of vitamin D deficiency in diabetic patients, and the relationship between vitamin D concentration and insulin resistance, fasting plasma glucose, and HbA1C in patients in Hue City, Vietnam.Methods: A cross-sectional study on 110 diabetic patients examined at Hue Central Hospital and Hue University of Medicine and Pharmacy Hospital. These patients were collected venous blood sampling, and the 25(OH)D test, fasting plasma glucose test, fasting insulin test, HOMA-IR and QUICKI calculation.Results: Vitamin D deficiency and insufficiency prevalence were 51.8%. The average concentration of 25(OH)D (ng/mL) was 30.67 ± 8.55; this concentration in fasting glucose level ≤ 8 mmol/l group and > 8 mmol/l group was 32.08 ± 9.26 and 28.55± 6.91 (p = 0.033); it was 32.95 ± 8.58 and 28.97 ± 8.17 in HOMA-IR ≤ 3.5 and HOMA-IR > 3.5 group, (p = 0.015); in QUICKI ≤ 0.32 group, it was 29.16 ± 8.12; in QUICKI > 0.32 group, it was 32.85 ± 8.76 (p = 0.025). Patients with an ideal exercise level have higher average levels of 25(OH)D (32.11± 8.62 vs 26.83± 7.16, p=0.003). The average levels of 25(OH)D in male patients are higher than in female patients (33.47± 0.08 vs 29.01± 8.43, p=0.008). Vitamin D deficiency and insufficiency prevalence in patients with HOMA-IR ≤ 3.5 and QUICKI > 0.32 were 36.2% and 37.8%, whereas in those with HOMA-IR > 3.5 and QUICKI ≤ 0.32 they were 63.5% and 61.5% (p = 0.007 and 0.02, respectively). 25(OH)D is negative correlation with fasting glucose level and HOMA-IR, with r = − 0.229 and − 0.192, respectively (p = 0.016 and 0.045); 25(OH)D was positively correlated with QUICKI, with r = 0.235, p = 0.008.Conclusion: Patients who have better glucose-related parameters, such as fasting blood sugar, HOMA-IR and QUICKI, have a better vitamin D status. Some blood sugar-related factors, such as exercise level and sex, are related to vitamin D status.Keywords: vitamin D, insulin resistance, diabetes, HbA1CTran Huu TTTran HDTran TNHoang BBDove Medical Pressarticlevitamin dinsulin resistancediabeteshba1cSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2489-2494 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin d insulin resistance diabetes hba1c Specialties of internal medicine RC581-951
spellingShingle	vitamin d insulin resistance diabetes hba1c Specialties of internal medicine RC581-951 Tran Huu TT Tran HD Tran TN Hoang BB Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes
description	Thanh Tung Tran Huu,1 Huu Dang Tran,2 Thua Nguyen Tran,3 Bui Bao Hoang2 1Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam; 2Department of Internal Medicine, Hue University of Medicine and Pharmacy, Hue City, Vietnam; 3Department of General Internal Medicine and Geriatrics, Hue Central Hospital, Hue City, VietnamCorrespondence: Thua Nguyen TranDepartment of General Internal Medicine and Geriatrics, Hue Central Hospital, Hue City, VietnamTel +84903597695Email tranthuanguyen23@gmail.comIntroduction: Clarifying the prevalence of vitamin D deficiency in diabetic patients, and the relationship between vitamin D concentration and insulin resistance, fasting plasma glucose, and HbA1C in patients in Hue City, Vietnam.Methods: A cross-sectional study on 110 diabetic patients examined at Hue Central Hospital and Hue University of Medicine and Pharmacy Hospital. These patients were collected venous blood sampling, and the 25(OH)D test, fasting plasma glucose test, fasting insulin test, HOMA-IR and QUICKI calculation.Results: Vitamin D deficiency and insufficiency prevalence were 51.8%. The average concentration of 25(OH)D (ng/mL) was 30.67 ± 8.55; this concentration in fasting glucose level ≤ 8 mmol/l group and > 8 mmol/l group was 32.08 ± 9.26 and 28.55± 6.91 (p = 0.033); it was 32.95 ± 8.58 and 28.97 ± 8.17 in HOMA-IR ≤ 3.5 and HOMA-IR > 3.5 group, (p = 0.015); in QUICKI ≤ 0.32 group, it was 29.16 ± 8.12; in QUICKI > 0.32 group, it was 32.85 ± 8.76 (p = 0.025). Patients with an ideal exercise level have higher average levels of 25(OH)D (32.11± 8.62 vs 26.83± 7.16, p=0.003). The average levels of 25(OH)D in male patients are higher than in female patients (33.47± 0.08 vs 29.01± 8.43, p=0.008). Vitamin D deficiency and insufficiency prevalence in patients with HOMA-IR ≤ 3.5 and QUICKI > 0.32 were 36.2% and 37.8%, whereas in those with HOMA-IR > 3.5 and QUICKI ≤ 0.32 they were 63.5% and 61.5% (p = 0.007 and 0.02, respectively). 25(OH)D is negative correlation with fasting glucose level and HOMA-IR, with r = − 0.229 and − 0.192, respectively (p = 0.016 and 0.045); 25(OH)D was positively correlated with QUICKI, with r = 0.235, p = 0.008.Conclusion: Patients who have better glucose-related parameters, such as fasting blood sugar, HOMA-IR and QUICKI, have a better vitamin D status. Some blood sugar-related factors, such as exercise level and sex, are related to vitamin D status.Keywords: vitamin D, insulin resistance, diabetes, HbA1C
format	article
author	Tran Huu TT Tran HD Tran TN Hoang BB
author_facet	Tran Huu TT Tran HD Tran TN Hoang BB
author_sort	Tran Huu TT
title	Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes
title_short	Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes
title_full	Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes
title_fullStr	Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes
title_full_unstemmed	Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes
title_sort	relationship between vitamin d status and the relevant parameters of glucose in patients with type 2 diabetes
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c800b2154ffa4b55ae30983138a7cba4
work_keys_str_mv	AT tranhuutt relationshipbetweenvitamindstatusandtherelevantparametersofglucoseinpatientswithtype2diabetes AT tranhd relationshipbetweenvitamindstatusandtherelevantparametersofglucoseinpatientswithtype2diabetes AT trantn relationshipbetweenvitamindstatusandtherelevantparametersofglucoseinpatientswithtype2diabetes AT hoangbb relationshipbetweenvitamindstatusandtherelevantparametersofglucoseinpatientswithtype2diabetes
_version_	1718378711114317824

Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes

Ejemplares similares