Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis

Introduction: Ectopic fat deposition in the pancreas is involved in the pathogenesis of metabolic sequelae following an attack of pancreatitis. However, its relationship with the exocrine pancreas has never been explored in this setting. The aim was to investigate the associations between intra-panc...

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Autores principales:	Juyeon Ko, Loren Skudder-Hill, Sunitha Priya, Wandia Kimita, Sakina H. Bharmal, Maxim S. Petrov
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	intra-pancreatic fat deposition pancreas volume pancreas size pancreatic enzymes body composition Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c8066af239b64e19bd55b2aeda7f7895
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spelling	oai:doaj.org-article:c8066af239b64e19bd55b2aeda7f78952021-12-02T12:40:22ZAssociations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis1662-40251662-403310.1159/000519621https://doaj.org/article/c8066af239b64e19bd55b2aeda7f78952021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/519621https://doaj.org/toc/1662-4025https://doaj.org/toc/1662-4033Introduction: Ectopic fat deposition in the pancreas is involved in the pathogenesis of metabolic sequelae following an attack of pancreatitis. However, its relationship with the exocrine pancreas has never been explored in this setting. The aim was to investigate the associations between intra-pancreatic fat deposition (IPFD), pancreas size, and pancreatic enzymes. Methods: This cross-sectional study recruited individuals with a history of acute pancreatitis and healthy controls. All participants underwent 3T magnetic resonance imaging, from which IPFD, total pancreas volume (TPV), and pancreas diameters (across the head, body, and tail) were measured independently by 2 raters in a blinded fashion. Circulating levels of pancreatic amylase, pancreatic lipase, and chymotrypsin were measured in a fasted state. A series of linear regression analyses was conducted, accounting for possible confounders. Results: A total of 108 individuals with pancreatitis and 60 healthy controls were studied. There was a statistically significant difference in IPFD (p < 0.001), but not in TPV (p = 0.389), between the groups. In the post-pancreatitis group, IPFD was significantly inversely associated with pancreas tail diameter (β = −0.736, p = 0.036 in the most adjusted model). In the control group, IPFD was significantly inversely associated with TPV (β = −3.557, p = 0.026 in the most adjusted model). Levels of pancreatic amylase were significantly directly associated with pancreas tail diameter in the post-pancreatitis group (β = 3.891, p = 0.042 in the most adjusted model), whereas levels of pancreatic lipase were significantly inversely associated with TPV in the control group (β = −10.533, p = 0.024 in the most adjusted model). Conclusion: Increased IPFD in individuals after an attack of pancreatitis is associated with reduced pancreas tail diameter, which is in turn associated with reduced circulating levels of pancreatic amylase. The relationship between IPFD and the exocrine pancreas warrants further investigations.Juyeon KoLoren Skudder-HillSunitha PriyaWandia KimitaSakina H. BharmalMaxim S. PetrovKarger Publishersarticleintra-pancreatic fat depositionpancreas volumepancreas sizepancreatic enzymesbody compositionNutrition. Foods and food supplyTX341-641Nutritional diseases. Deficiency diseasesRC620-627ENObesity Facts, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intra-pancreatic fat deposition pancreas volume pancreas size pancreatic enzymes body composition Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	intra-pancreatic fat deposition pancreas volume pancreas size pancreatic enzymes body composition Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627 Juyeon Ko Loren Skudder-Hill Sunitha Priya Wandia Kimita Sakina H. Bharmal Maxim S. Petrov Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis
description	Introduction: Ectopic fat deposition in the pancreas is involved in the pathogenesis of metabolic sequelae following an attack of pancreatitis. However, its relationship with the exocrine pancreas has never been explored in this setting. The aim was to investigate the associations between intra-pancreatic fat deposition (IPFD), pancreas size, and pancreatic enzymes. Methods: This cross-sectional study recruited individuals with a history of acute pancreatitis and healthy controls. All participants underwent 3T magnetic resonance imaging, from which IPFD, total pancreas volume (TPV), and pancreas diameters (across the head, body, and tail) were measured independently by 2 raters in a blinded fashion. Circulating levels of pancreatic amylase, pancreatic lipase, and chymotrypsin were measured in a fasted state. A series of linear regression analyses was conducted, accounting for possible confounders. Results: A total of 108 individuals with pancreatitis and 60 healthy controls were studied. There was a statistically significant difference in IPFD (p < 0.001), but not in TPV (p = 0.389), between the groups. In the post-pancreatitis group, IPFD was significantly inversely associated with pancreas tail diameter (β = −0.736, p = 0.036 in the most adjusted model). In the control group, IPFD was significantly inversely associated with TPV (β = −3.557, p = 0.026 in the most adjusted model). Levels of pancreatic amylase were significantly directly associated with pancreas tail diameter in the post-pancreatitis group (β = 3.891, p = 0.042 in the most adjusted model), whereas levels of pancreatic lipase were significantly inversely associated with TPV in the control group (β = −10.533, p = 0.024 in the most adjusted model). Conclusion: Increased IPFD in individuals after an attack of pancreatitis is associated with reduced pancreas tail diameter, which is in turn associated with reduced circulating levels of pancreatic amylase. The relationship between IPFD and the exocrine pancreas warrants further investigations.
format	article
author	Juyeon Ko Loren Skudder-Hill Sunitha Priya Wandia Kimita Sakina H. Bharmal Maxim S. Petrov
author_facet	Juyeon Ko Loren Skudder-Hill Sunitha Priya Wandia Kimita Sakina H. Bharmal Maxim S. Petrov
author_sort	Juyeon Ko
title	Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis
title_short	Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis
title_full	Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis
title_fullStr	Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis
title_full_unstemmed	Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis
title_sort	associations between intra-pancreatic fat deposition, pancreas size, and pancreatic enzymes in health and after an attack of acute pancreatitis
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/c8066af239b64e19bd55b2aeda7f7895
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Associations between Intra-Pancreatic Fat Deposition, Pancreas Size, and Pancreatic Enzymes in Health and after an Attack of Acute Pancreatitis

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