Phylogenetic analysis of F-bZIP transcription factors indicates conservation of the zinc deficiency response across land plants

Abstract Basic leucine zipper (bZIP) transcription factors control important developmental and physiological processes in plants. In Arabidopsis thaliana, the three gene F-bZIP subfamily has been associated with zinc deficiency and salt stress response. Benefiting from the present abundance of plant...

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Autores principales:	Pedro Humberto Castro, Grmay H. Lilay, Antonio Muñoz-Mérida, Jan K. Schjoerring, Herlânder Azevedo, Ana G. L. Assunção
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c8093524ceff48c28020b2521f69f413
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spelling	oai:doaj.org-article:c8093524ceff48c28020b2521f69f4132021-12-02T12:32:16ZPhylogenetic analysis of F-bZIP transcription factors indicates conservation of the zinc deficiency response across land plants10.1038/s41598-017-03903-62045-2322https://doaj.org/article/c8093524ceff48c28020b2521f69f4132017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03903-6https://doaj.org/toc/2045-2322Abstract Basic leucine zipper (bZIP) transcription factors control important developmental and physiological processes in plants. In Arabidopsis thaliana, the three gene F-bZIP subfamily has been associated with zinc deficiency and salt stress response. Benefiting from the present abundance of plant genomic data, we performed an evolutionary and structural characterization of plant F-bZIPs. We observed divergence during seed plant evolution, into two groups and inferred different selective pressures for each. Group 1 contains AtbZIP19 and AtbZIP23 and appears more conserved, whereas Group 2, containing AtbZIP24, is more prone to gene loss and expansion events. Transcriptomic and experimental data reinforced AtbZIP19/23 as pivotal regulators of the zinc deficiency response, mostly via the activation of genes from the ZIP metal transporter family, and revealed that they are the main regulatory switch of AtZIP4. A survey of AtZIP4 orthologs promoters across different plant taxa revealed an enrichment of the Zinc Deficiency Response Element (ZDRE) to which both AtbZIP19/23 bind. Overall, our results indicate that while the AtbZIP24 function in the regulation of the salt stress response may be the result of neo-functionalization, the AtbZIP19/23 function in the regulation of the zinc deficiency response may be conserved in land plants (Embryophytes).Pedro Humberto CastroGrmay H. LilayAntonio Muñoz-MéridaJan K. SchjoerringHerlânder AzevedoAna G. L. AssunçãoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pedro Humberto Castro Grmay H. Lilay Antonio Muñoz-Mérida Jan K. Schjoerring Herlânder Azevedo Ana G. L. Assunção Phylogenetic analysis of F-bZIP transcription factors indicates conservation of the zinc deficiency response across land plants
description	Abstract Basic leucine zipper (bZIP) transcription factors control important developmental and physiological processes in plants. In Arabidopsis thaliana, the three gene F-bZIP subfamily has been associated with zinc deficiency and salt stress response. Benefiting from the present abundance of plant genomic data, we performed an evolutionary and structural characterization of plant F-bZIPs. We observed divergence during seed plant evolution, into two groups and inferred different selective pressures for each. Group 1 contains AtbZIP19 and AtbZIP23 and appears more conserved, whereas Group 2, containing AtbZIP24, is more prone to gene loss and expansion events. Transcriptomic and experimental data reinforced AtbZIP19/23 as pivotal regulators of the zinc deficiency response, mostly via the activation of genes from the ZIP metal transporter family, and revealed that they are the main regulatory switch of AtZIP4. A survey of AtZIP4 orthologs promoters across different plant taxa revealed an enrichment of the Zinc Deficiency Response Element (ZDRE) to which both AtbZIP19/23 bind. Overall, our results indicate that while the AtbZIP24 function in the regulation of the salt stress response may be the result of neo-functionalization, the AtbZIP19/23 function in the regulation of the zinc deficiency response may be conserved in land plants (Embryophytes).
format	article
author	Pedro Humberto Castro Grmay H. Lilay Antonio Muñoz-Mérida Jan K. Schjoerring Herlânder Azevedo Ana G. L. Assunção
author_facet	Pedro Humberto Castro Grmay H. Lilay Antonio Muñoz-Mérida Jan K. Schjoerring Herlânder Azevedo Ana G. L. Assunção
author_sort	Pedro Humberto Castro
title	Phylogenetic analysis of F-bZIP transcription factors indicates conservation of the zinc deficiency response across land plants
title_short	Phylogenetic analysis of F-bZIP transcription factors indicates conservation of the zinc deficiency response across land plants
title_full	Phylogenetic analysis of F-bZIP transcription factors indicates conservation of the zinc deficiency response across land plants
title_fullStr	Phylogenetic analysis of F-bZIP transcription factors indicates conservation of the zinc deficiency response across land plants
title_full_unstemmed	Phylogenetic analysis of F-bZIP transcription factors indicates conservation of the zinc deficiency response across land plants
title_sort	phylogenetic analysis of f-bzip transcription factors indicates conservation of the zinc deficiency response across land plants
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c8093524ceff48c28020b2521f69f413
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Phylogenetic analysis of F-bZIP transcription factors indicates conservation of the zinc deficiency response across land plants

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