Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway

Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway

Biotin is an essential enzyme cofactor and two pathways for the generation of the biotin precursor pimeloyl-ACP are known. Here, the authors identify and characterize a third pathway for biotin precursor synthesis involving BioZ and they also present the Agrobacterium tumefaciens BioZ crystal struct...

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Autores principales: Sitao Zhang, Yongchang Xu, Hongxin Guan, Tao Cui, Yuling Liao, Wenhui Wei, Jun Li, Bachar H. Hassan, Huimin Zhang, Xu Jia, Songying Ouyang, Youjun Feng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c80e552cb1354f92b240e8c666740d25
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spelling oai:doaj.org-article:c80e552cb1354f92b240e8c666740d252021-12-02T18:15:27ZBiochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway10.1038/s41467-021-22360-42041-1723https://doaj.org/article/c80e552cb1354f92b240e8c666740d252021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22360-4https://doaj.org/toc/2041-1723Biotin is an essential enzyme cofactor and two pathways for the generation of the biotin precursor pimeloyl-ACP are known. Here, the authors identify and characterize a third pathway for biotin precursor synthesis involving BioZ and they also present the Agrobacterium tumefaciens BioZ crystal structure.Sitao ZhangYongchang XuHongxin GuanTao CuiYuling LiaoWenhui WeiJun LiBachar H. HassanHuimin ZhangXu JiaSongying OuyangYoujun FengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sitao Zhang
Yongchang Xu
Hongxin Guan
Tao Cui
Yuling Liao
Wenhui Wei
Jun Li
Bachar H. Hassan
Huimin Zhang
Xu Jia
Songying Ouyang
Youjun Feng
Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway
description Biotin is an essential enzyme cofactor and two pathways for the generation of the biotin precursor pimeloyl-ACP are known. Here, the authors identify and characterize a third pathway for biotin precursor synthesis involving BioZ and they also present the Agrobacterium tumefaciens BioZ crystal structure.
format article
author Sitao Zhang
Yongchang Xu
Hongxin Guan
Tao Cui
Yuling Liao
Wenhui Wei
Jun Li
Bachar H. Hassan
Huimin Zhang
Xu Jia
Songying Ouyang
Youjun Feng
author_facet Sitao Zhang
Yongchang Xu
Hongxin Guan
Tao Cui
Yuling Liao
Wenhui Wei
Jun Li
Bachar H. Hassan
Huimin Zhang
Xu Jia
Songying Ouyang
Youjun Feng
author_sort Sitao Zhang
title Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway
title_short Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway
title_full Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway
title_fullStr Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway
title_full_unstemmed Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway
title_sort biochemical and structural characterization of the bioz enzyme engaged in bacterial biotin synthesis pathway
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c80e552cb1354f92b240e8c666740d25
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AT yongchangxu biochemicalandstructuralcharacterizationofthebiozenzymeengagedinbacterialbiotinsynthesispathway
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AT taocui biochemicalandstructuralcharacterizationofthebiozenzymeengagedinbacterialbiotinsynthesispathway
AT yulingliao biochemicalandstructuralcharacterizationofthebiozenzymeengagedinbacterialbiotinsynthesispathway
AT wenhuiwei biochemicalandstructuralcharacterizationofthebiozenzymeengagedinbacterialbiotinsynthesispathway
AT junli biochemicalandstructuralcharacterizationofthebiozenzymeengagedinbacterialbiotinsynthesispathway
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AT huiminzhang biochemicalandstructuralcharacterizationofthebiozenzymeengagedinbacterialbiotinsynthesispathway
AT xujia biochemicalandstructuralcharacterizationofthebiozenzymeengagedinbacterialbiotinsynthesispathway
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AT youjunfeng biochemicalandstructuralcharacterizationofthebiozenzymeengagedinbacterialbiotinsynthesispathway
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