Mycobacterium tuberculosis progresses through two phases of latent infection in humans

Here, Colangeli et al. use a human household contact cohort to measure the rate of mutation and evolution of Mycobacterium tuberculosis strains and find that long term latency is characterized by reduced mutation rates compared to latency in the first year, coinciding with clinical risk of developin...

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Autores principales:	Roberto Colangeli, Aditi Gupta, Solange Alves Vinhas, Uma Deepthi Chippada Venkata, Soyeon Kim, Courtney Grady, Edward C. Jones-López, Patricia Soteropoulos, Moisés Palaci, Patrícia Marques-Rodrigues, Padmini Salgame, Jerrold J. Ellner, Reynaldo Dietze, David Alland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8190181e06b4d39af146506e44cad8c
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spelling	oai:doaj.org-article:c8190181e06b4d39af146506e44cad8c2021-12-02T15:15:23ZMycobacterium tuberculosis progresses through two phases of latent infection in humans10.1038/s41467-020-18699-92041-1723https://doaj.org/article/c8190181e06b4d39af146506e44cad8c2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18699-9https://doaj.org/toc/2041-1723Here, Colangeli et al. use a human household contact cohort to measure the rate of mutation and evolution of Mycobacterium tuberculosis strains and find that long term latency is characterized by reduced mutation rates compared to latency in the first year, coinciding with clinical risk of developing active TB.Roberto ColangeliAditi GuptaSolange Alves VinhasUma Deepthi Chippada VenkataSoyeon KimCourtney GradyEdward C. Jones-LópezPatricia SoteropoulosMoisés PalaciPatrícia Marques-RodriguesPadmini SalgameJerrold J. EllnerReynaldo DietzeDavid AllandNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roberto Colangeli Aditi Gupta Solange Alves Vinhas Uma Deepthi Chippada Venkata Soyeon Kim Courtney Grady Edward C. Jones-López Patricia Soteropoulos Moisés Palaci Patrícia Marques-Rodrigues Padmini Salgame Jerrold J. Ellner Reynaldo Dietze David Alland Mycobacterium tuberculosis progresses through two phases of latent infection in humans
description	Here, Colangeli et al. use a human household contact cohort to measure the rate of mutation and evolution of Mycobacterium tuberculosis strains and find that long term latency is characterized by reduced mutation rates compared to latency in the first year, coinciding with clinical risk of developing active TB.
format	article
author	Roberto Colangeli Aditi Gupta Solange Alves Vinhas Uma Deepthi Chippada Venkata Soyeon Kim Courtney Grady Edward C. Jones-López Patricia Soteropoulos Moisés Palaci Patrícia Marques-Rodrigues Padmini Salgame Jerrold J. Ellner Reynaldo Dietze David Alland
author_facet	Roberto Colangeli Aditi Gupta Solange Alves Vinhas Uma Deepthi Chippada Venkata Soyeon Kim Courtney Grady Edward C. Jones-López Patricia Soteropoulos Moisés Palaci Patrícia Marques-Rodrigues Padmini Salgame Jerrold J. Ellner Reynaldo Dietze David Alland
author_sort	Roberto Colangeli
title	Mycobacterium tuberculosis progresses through two phases of latent infection in humans
title_short	Mycobacterium tuberculosis progresses through two phases of latent infection in humans
title_full	Mycobacterium tuberculosis progresses through two phases of latent infection in humans
title_fullStr	Mycobacterium tuberculosis progresses through two phases of latent infection in humans
title_full_unstemmed	Mycobacterium tuberculosis progresses through two phases of latent infection in humans
title_sort	mycobacterium tuberculosis progresses through two phases of latent infection in humans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c8190181e06b4d39af146506e44cad8c
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Mycobacterium tuberculosis progresses through two phases of latent infection in humans

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