Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats

Abstract Cocaine can induce severe neurobehavioral changes, among others, the ones involved in learning and memory processes. It is known that during drug consumption, cocaine-associated memory and learning processes take place. However, much less is known about the effects of this drug upon the mec...

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Autores principales:	Rosa López-Pedrajas, Inmaculada Almansa, María V. Sánchez-Villarejo, Borja Muriach, Jorge M. Barcia, Francisco J. Romero, María Muriach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c81a760139b040a887313c265124faa3
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spelling	oai:doaj.org-article:c81a760139b040a887313c265124faa32021-12-02T18:01:48ZRole of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats10.1038/s41598-021-99448-w2045-2322https://doaj.org/article/c81a760139b040a887313c265124faa32021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99448-whttps://doaj.org/toc/2045-2322Abstract Cocaine can induce severe neurobehavioral changes, among others, the ones involved in learning and memory processes. It is known that during drug consumption, cocaine-associated memory and learning processes take place. However, much less is known about the effects of this drug upon the mechanisms involved in forgetting.The present report focuses on the mechanisms by which cocaine affects memory consolidation of experiences acquired prior to drug administration. We also study the involvement of hippocampus in these processes, with special interest on the role of Nuclear factor kappa B (NF-κB), N-methyl-D-aspartate glutamate receptor 2B (GluN2B), and their relationship with other proteins, such as cyclic AMP response element binding protein (CREB). For this purpose, we developed a rat experimental model of chronic cocaine administration in which spatial memory and the expression or activity of several proteins in the hippocampus were assessed after 36 days of drug administration. We report an impairment in memory acquisition of experiences gathered prior to cocaine administration, associated to an increase in GluN2B expression in the hippocampus. We also demonstrate a decrease in NF-κB activity, as well as in the expression of the active form of CREB, confirming the role of these transcription factors in the cocaine-induced memory impairment.Rosa López-PedrajasInmaculada AlmansaMaría V. Sánchez-VillarejoBorja MuriachJorge M. BarciaFrancisco J. RomeroMaría MuriachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rosa López-Pedrajas Inmaculada Almansa María V. Sánchez-Villarejo Borja Muriach Jorge M. Barcia Francisco J. Romero María Muriach Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats
description	Abstract Cocaine can induce severe neurobehavioral changes, among others, the ones involved in learning and memory processes. It is known that during drug consumption, cocaine-associated memory and learning processes take place. However, much less is known about the effects of this drug upon the mechanisms involved in forgetting.The present report focuses on the mechanisms by which cocaine affects memory consolidation of experiences acquired prior to drug administration. We also study the involvement of hippocampus in these processes, with special interest on the role of Nuclear factor kappa B (NF-κB), N-methyl-D-aspartate glutamate receptor 2B (GluN2B), and their relationship with other proteins, such as cyclic AMP response element binding protein (CREB). For this purpose, we developed a rat experimental model of chronic cocaine administration in which spatial memory and the expression or activity of several proteins in the hippocampus were assessed after 36 days of drug administration. We report an impairment in memory acquisition of experiences gathered prior to cocaine administration, associated to an increase in GluN2B expression in the hippocampus. We also demonstrate a decrease in NF-κB activity, as well as in the expression of the active form of CREB, confirming the role of these transcription factors in the cocaine-induced memory impairment.
format	article
author	Rosa López-Pedrajas Inmaculada Almansa María V. Sánchez-Villarejo Borja Muriach Jorge M. Barcia Francisco J. Romero María Muriach
author_facet	Rosa López-Pedrajas Inmaculada Almansa María V. Sánchez-Villarejo Borja Muriach Jorge M. Barcia Francisco J. Romero María Muriach
author_sort	Rosa López-Pedrajas
title	Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats
title_short	Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats
title_full	Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats
title_fullStr	Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats
title_full_unstemmed	Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats
title_sort	role of hippocampal nf-κb and glun2b in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c81a760139b040a887313c265124faa3
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Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats

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