COMPARISON OF EFFICACY OF COMBINATION OF 2% KETOCONAZOLE SOLUTION WASH AND TOPICAL 1% CLOTRIMAZOLE WITH TOPICAL 1% CLOTRIMAZOLE ALONE IN C

Objective: Comparison of efficacy of combination comprising 2% ketoconazole solution wash plus topical 1% clotrimazole versus topical 1% clotrimazole alone in management of patients with Pityriasis versicolor. Study Design: Randomized controlled trial. Place and Duration of Study: Dermatolo...

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Autores principales:	Ayesha Anwar, Naeem Raza, Najia Ahmed, Hyder Ali Awan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	pityriasis versicolor clotrimazole fungal hyphae Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c81cf541f5d84d458e0fe702f547527f
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spelling	oai:doaj.org-article:c81cf541f5d84d458e0fe702f547527f2021-11-30T02:52:15ZCOMPARISON OF EFFICACY OF COMBINATION OF 2% KETOCONAZOLE SOLUTION WASH AND TOPICAL 1% CLOTRIMAZOLE WITH TOPICAL 1% CLOTRIMAZOLE ALONE IN C0030-96482411-8842https://doaj.org/article/c81cf541f5d84d458e0fe702f547527f2018-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2596/2118https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: Comparison of efficacy of combination comprising 2% ketoconazole solution wash plus topical 1% clotrimazole versus topical 1% clotrimazole alone in management of patients with Pityriasis versicolor. Study Design: Randomized controlled trial. Place and Duration of Study: Dermatology department, Pak Emirates Military Hospital Rawalpindi, from Oct 2016 to Apr 2017. Material and Methods: Sixty patients of Pityriasis versicolor, both male and female were included in study. Diagnosis of Pityriasis versicolor was made clinically and confirmed microscopically by examining skin scrapings for fungal hyphae. Patients with concomitant systemic illnesses or those who had received anti-fungal in last three months were excluded from study. Random number tables were used to allocate patients to the two treatment groups. Group A received 2% ketoconazole shampoo twice per week for four weeks plus topical 1% clotrimazole twice daily application for 2 weeks. Group B received only topical therapy with 1% clotrimazole cream applied twice daily for 2 weeks. Assessment of treatment efficacy was done by clinical examination of patient and microscopy of skin scrapping for fungal hyphaedone at baseline and at end of study (4 weeks of treatment). A negative clinical examination and negative skin scrapping for fungal hyphae was considered effective therapeutic response. Results: In group A, the mean age of patients was 29.76 ± 8.89 years and in group B was 27.67 ± 10.46 years. Efficacy in group A was observed in 22 (73.33%) patients while in group B in 14 (46.67%) patients. Conclusion: Combination of 2% ketoconazole solution wash plus topical 1% clotrimazole was found more effective in treatment of patients with Pityriasis versicolor as compared totopical 1% clotrimazole alone.Ayesha AnwarNaeem RazaNajia AhmedHyder Ali AwanArmy Medical College Rawalpindiarticlepityriasis versicolorclotrimazolefungal hyphaeMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 6, Pp 1725-1730 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	pityriasis versicolor clotrimazole fungal hyphae Medicine R Medicine (General) R5-920
spellingShingle	pityriasis versicolor clotrimazole fungal hyphae Medicine R Medicine (General) R5-920 Ayesha Anwar Naeem Raza Najia Ahmed Hyder Ali Awan COMPARISON OF EFFICACY OF COMBINATION OF 2% KETOCONAZOLE SOLUTION WASH AND TOPICAL 1% CLOTRIMAZOLE WITH TOPICAL 1% CLOTRIMAZOLE ALONE IN C
description	Objective: Comparison of efficacy of combination comprising 2% ketoconazole solution wash plus topical 1% clotrimazole versus topical 1% clotrimazole alone in management of patients with Pityriasis versicolor. Study Design: Randomized controlled trial. Place and Duration of Study: Dermatology department, Pak Emirates Military Hospital Rawalpindi, from Oct 2016 to Apr 2017. Material and Methods: Sixty patients of Pityriasis versicolor, both male and female were included in study. Diagnosis of Pityriasis versicolor was made clinically and confirmed microscopically by examining skin scrapings for fungal hyphae. Patients with concomitant systemic illnesses or those who had received anti-fungal in last three months were excluded from study. Random number tables were used to allocate patients to the two treatment groups. Group A received 2% ketoconazole shampoo twice per week for four weeks plus topical 1% clotrimazole twice daily application for 2 weeks. Group B received only topical therapy with 1% clotrimazole cream applied twice daily for 2 weeks. Assessment of treatment efficacy was done by clinical examination of patient and microscopy of skin scrapping for fungal hyphaedone at baseline and at end of study (4 weeks of treatment). A negative clinical examination and negative skin scrapping for fungal hyphae was considered effective therapeutic response. Results: In group A, the mean age of patients was 29.76 ± 8.89 years and in group B was 27.67 ± 10.46 years. Efficacy in group A was observed in 22 (73.33%) patients while in group B in 14 (46.67%) patients. Conclusion: Combination of 2% ketoconazole solution wash plus topical 1% clotrimazole was found more effective in treatment of patients with Pityriasis versicolor as compared totopical 1% clotrimazole alone.
format	article
author	Ayesha Anwar Naeem Raza Najia Ahmed Hyder Ali Awan
author_facet	Ayesha Anwar Naeem Raza Najia Ahmed Hyder Ali Awan
author_sort	Ayesha Anwar
title	COMPARISON OF EFFICACY OF COMBINATION OF 2% KETOCONAZOLE SOLUTION WASH AND TOPICAL 1% CLOTRIMAZOLE WITH TOPICAL 1% CLOTRIMAZOLE ALONE IN C
title_short	COMPARISON OF EFFICACY OF COMBINATION OF 2% KETOCONAZOLE SOLUTION WASH AND TOPICAL 1% CLOTRIMAZOLE WITH TOPICAL 1% CLOTRIMAZOLE ALONE IN C
title_full	COMPARISON OF EFFICACY OF COMBINATION OF 2% KETOCONAZOLE SOLUTION WASH AND TOPICAL 1% CLOTRIMAZOLE WITH TOPICAL 1% CLOTRIMAZOLE ALONE IN C
title_fullStr	COMPARISON OF EFFICACY OF COMBINATION OF 2% KETOCONAZOLE SOLUTION WASH AND TOPICAL 1% CLOTRIMAZOLE WITH TOPICAL 1% CLOTRIMAZOLE ALONE IN C
title_full_unstemmed	COMPARISON OF EFFICACY OF COMBINATION OF 2% KETOCONAZOLE SOLUTION WASH AND TOPICAL 1% CLOTRIMAZOLE WITH TOPICAL 1% CLOTRIMAZOLE ALONE IN C
title_sort	comparison of efficacy of combination of 2% ketoconazole solution wash and topical 1% clotrimazole with topical 1% clotrimazole alone in c
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/c81cf541f5d84d458e0fe702f547527f
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COMPARISON OF EFFICACY OF COMBINATION OF 2% KETOCONAZOLE SOLUTION WASH AND TOPICAL 1% CLOTRIMAZOLE WITH TOPICAL 1% CLOTRIMAZOLE ALONE IN C

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