Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study

Abstract Background This study seeks to understand better the mechanisms underlying the increased risk of caries in HIV-infected school-aged Nigerian children by examining the relationship between the plaque microbiome and perinatal HIV infection and exposure. We also seek to investigate how perinat...

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Autores principales:	Modupe O. Coker, Paul Akhigbe, Esosa Osagie, Nosakhare L. Idemudia, Oghenero Igedegbe, Nneka Chukwumah, Ruxton Adebiyi, Allison E. Mann, Lauren M. O’Connell, Ozo Obuekwe, Augustine Omoigberale, Manhattan E. Charurat, Vincent P. Richards
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	HIV Caries Oral microbiome Cohort Children Dental plaque Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/c81f0bab1f024286b7a277f4133dea88
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spelling	oai:doaj.org-article:c81f0bab1f024286b7a277f4133dea882021-12-05T12:20:34ZDental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study10.1186/s12903-021-01944-y1472-6831https://doaj.org/article/c81f0bab1f024286b7a277f4133dea882021-12-01T00:00:00Zhttps://doi.org/10.1186/s12903-021-01944-yhttps://doaj.org/toc/1472-6831Abstract Background This study seeks to understand better the mechanisms underlying the increased risk of caries in HIV-infected school-aged Nigerian children by examining the relationship between the plaque microbiome and perinatal HIV infection and exposure. We also seek to investigate how perinatal HIV infection and exposure impact tooth-specific microbiomes' role on caries disease progression. Methods The participants in this study were children aged 4 to 11 years recruited from the University of Benin Teaching Hospital (UBTH), Nigeria, between May to November 2019. Overall, 568 children were enrolled in three groups: 189 HIV-infected (HI), 189 HIV-exposed but uninfected (HEU) and 190 HIV-unexposed and uninfected (HUU) as controls at visit 1 with a 2.99% and 4.90% attrition rate at visit 2 and visit 3 respectively. Data were obtained with standardized questionnaires. Blood samples were collected for HIV, HBV and HCV screening; CD4, CD8 and full blood count analysis; and plasma samples stored for future investigations; oral samples including saliva, buccal swabs, oropharyngeal swab, tongue swab, dental plaque were collected aseptically from participants at different study visits. Conclusions Results from the study will provide critical information on how HIV exposure, infection, and treatment, influence the oral microbiome and caries susceptibility in children. By determining the effect on community taxonomic structure and gene expression of dental microbiomes, we will elucidate mechanisms that potentially create a predisposition for developing dental caries. As future plans, the relationship between respiratory tract infections, immune and inflammatory markers with dental caries in perinatal HIV infection and exposure will be investigated.Modupe O. CokerPaul AkhigbeEsosa OsagieNosakhare L. IdemudiaOghenero IgedegbeNneka ChukwumahRuxton AdebiyiAllison E. MannLauren M. O’ConnellOzo ObuekweAugustine OmoigberaleManhattan E. CharuratVincent P. RichardsBMCarticleHIVCariesOral microbiomeCohortChildrenDental plaqueDentistryRK1-715ENBMC Oral Health, Vol 21, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV Caries Oral microbiome Cohort Children Dental plaque Dentistry RK1-715
spellingShingle	HIV Caries Oral microbiome Cohort Children Dental plaque Dentistry RK1-715 Modupe O. Coker Paul Akhigbe Esosa Osagie Nosakhare L. Idemudia Oghenero Igedegbe Nneka Chukwumah Ruxton Adebiyi Allison E. Mann Lauren M. O’Connell Ozo Obuekwe Augustine Omoigberale Manhattan E. Charurat Vincent P. Richards Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study
description	Abstract Background This study seeks to understand better the mechanisms underlying the increased risk of caries in HIV-infected school-aged Nigerian children by examining the relationship between the plaque microbiome and perinatal HIV infection and exposure. We also seek to investigate how perinatal HIV infection and exposure impact tooth-specific microbiomes' role on caries disease progression. Methods The participants in this study were children aged 4 to 11 years recruited from the University of Benin Teaching Hospital (UBTH), Nigeria, between May to November 2019. Overall, 568 children were enrolled in three groups: 189 HIV-infected (HI), 189 HIV-exposed but uninfected (HEU) and 190 HIV-unexposed and uninfected (HUU) as controls at visit 1 with a 2.99% and 4.90% attrition rate at visit 2 and visit 3 respectively. Data were obtained with standardized questionnaires. Blood samples were collected for HIV, HBV and HCV screening; CD4, CD8 and full blood count analysis; and plasma samples stored for future investigations; oral samples including saliva, buccal swabs, oropharyngeal swab, tongue swab, dental plaque were collected aseptically from participants at different study visits. Conclusions Results from the study will provide critical information on how HIV exposure, infection, and treatment, influence the oral microbiome and caries susceptibility in children. By determining the effect on community taxonomic structure and gene expression of dental microbiomes, we will elucidate mechanisms that potentially create a predisposition for developing dental caries. As future plans, the relationship between respiratory tract infections, immune and inflammatory markers with dental caries in perinatal HIV infection and exposure will be investigated.
format	article
author	Modupe O. Coker Paul Akhigbe Esosa Osagie Nosakhare L. Idemudia Oghenero Igedegbe Nneka Chukwumah Ruxton Adebiyi Allison E. Mann Lauren M. O’Connell Ozo Obuekwe Augustine Omoigberale Manhattan E. Charurat Vincent P. Richards
author_facet	Modupe O. Coker Paul Akhigbe Esosa Osagie Nosakhare L. Idemudia Oghenero Igedegbe Nneka Chukwumah Ruxton Adebiyi Allison E. Mann Lauren M. O’Connell Ozo Obuekwe Augustine Omoigberale Manhattan E. Charurat Vincent P. Richards
author_sort	Modupe O. Coker
title	Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study
title_short	Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study
title_full	Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study
title_fullStr	Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study
title_full_unstemmed	Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study
title_sort	dental caries and its association with the oral microbiomes and hiv in young children—nigeria (domhain): a cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c81f0bab1f024286b7a277f4133dea88
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Dental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study

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