Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique

(1) Background: Sentinel lymph node staging (SLN) with indocyanine green (ICG) in cervical cancer is the standard of care in most national and international guidelines. However, the vast majority of relevant studies about the safety and feasibility of this method are conducted on minimally invasive...

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Autores principales:	Mustafa Zelal Muallem, Ahmad Sayasneh, Robert Armbrust, Jalid Sehouli, Andrea Miranda
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sentinel lymph node cervical cancer radical hysterectomy indocyanine green SPY-Portable Handheld Imager SPY-PHI Medicine R
Acceso en línea:	https://doaj.org/article/c82136dae46440dda68a24a9c88e7931
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spelling	oai:doaj.org-article:c82136dae46440dda68a24a9c88e79312021-11-11T17:30:50ZSentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique10.3390/jcm102148492077-0383https://doaj.org/article/c82136dae46440dda68a24a9c88e79312021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4849https://doaj.org/toc/2077-0383(1) Background: Sentinel lymph node staging (SLN) with indocyanine green (ICG) in cervical cancer is the standard of care in most national and international guidelines. However, the vast majority of relevant studies about the safety and feasibility of this method are conducted on minimally invasive surgery; (2) Methods: This study is a retrospective analysis of a retrospective collected database of 76 consecutive patients with cervical cancers, who were operated laparoscopically (50%), or laparotomy (50%). Sentinel nodes were defined as the ICG-positive pelvic nodes in the first and second echelons. False negative cases were defined as positive non-sentinel lymph nodes despite successful sentinel mapping or failed mapping bilaterally by per-patient assessment or unilaterally by pelvic sidewall assessment; (3) Results: Regardless of the approach (open or laparoscopic), the SLN technique achieved a total sensitivity, specificity, and negative predictive value (NPV) of 94.7%, 98.6%, and 94.7%, respectively in the entire sample. The bilateral detection rate was as high as 93.4% with identical results in both approaches. The sensitivity and NPV for SNL in open surgery was found to be similar to minimal access surgery; (4) Conclusions: ICG and SPY-PHI technique is a reliable tool to detect sentinel lymph nodes in cervical cancer during laparotomy.Mustafa Zelal MuallemAhmad SayasnehRobert ArmbrustJalid SehouliAndrea MirandaMDPI AGarticlesentinel lymph nodecervical cancerradical hysterectomyindocyanine greenSPY-Portable Handheld ImagerSPY-PHIMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4849, p 4849 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sentinel lymph node cervical cancer radical hysterectomy indocyanine green SPY-Portable Handheld Imager SPY-PHI Medicine R
spellingShingle	sentinel lymph node cervical cancer radical hysterectomy indocyanine green SPY-Portable Handheld Imager SPY-PHI Medicine R Mustafa Zelal Muallem Ahmad Sayasneh Robert Armbrust Jalid Sehouli Andrea Miranda Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique
description	(1) Background: Sentinel lymph node staging (SLN) with indocyanine green (ICG) in cervical cancer is the standard of care in most national and international guidelines. However, the vast majority of relevant studies about the safety and feasibility of this method are conducted on minimally invasive surgery; (2) Methods: This study is a retrospective analysis of a retrospective collected database of 76 consecutive patients with cervical cancers, who were operated laparoscopically (50%), or laparotomy (50%). Sentinel nodes were defined as the ICG-positive pelvic nodes in the first and second echelons. False negative cases were defined as positive non-sentinel lymph nodes despite successful sentinel mapping or failed mapping bilaterally by per-patient assessment or unilaterally by pelvic sidewall assessment; (3) Results: Regardless of the approach (open or laparoscopic), the SLN technique achieved a total sensitivity, specificity, and negative predictive value (NPV) of 94.7%, 98.6%, and 94.7%, respectively in the entire sample. The bilateral detection rate was as high as 93.4% with identical results in both approaches. The sensitivity and NPV for SNL in open surgery was found to be similar to minimal access surgery; (4) Conclusions: ICG and SPY-PHI technique is a reliable tool to detect sentinel lymph nodes in cervical cancer during laparotomy.
format	article
author	Mustafa Zelal Muallem Ahmad Sayasneh Robert Armbrust Jalid Sehouli Andrea Miranda
author_facet	Mustafa Zelal Muallem Ahmad Sayasneh Robert Armbrust Jalid Sehouli Andrea Miranda
author_sort	Mustafa Zelal Muallem
title	Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique
title_short	Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique
title_full	Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique
title_fullStr	Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique
title_full_unstemmed	Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique
title_sort	sentinel lymph node staging with indocyanine green for patients with cervical cancer: the safety and feasibility of open approach using spy-phi technique
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c82136dae46440dda68a24a9c88e7931
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Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique

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