Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production

The efficiency of producing glutarate, a valuable platform C5 compound, by engineered E. coli is low. Here, the authors achieve high titer and yield of glutarate production by pushing and pulling carbon flux in the native pathway and increasing intermediate influx using newly identified transporters...

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Autores principales:	Wenna Li, Lin Ma, Xiaolin Shen, Jia Wang, Qi Feng, Lexuan Liu, Guojun Zheng, Yajun Yan, Xinxiao Sun, Qipeng Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c821ea95ffe547eca9ec46dce1692df0
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spelling	oai:doaj.org-article:c821ea95ffe547eca9ec46dce1692df02021-12-02T16:57:54ZTargeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production10.1038/s41467-019-11289-42041-1723https://doaj.org/article/c821ea95ffe547eca9ec46dce1692df02019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11289-4https://doaj.org/toc/2041-1723The efficiency of producing glutarate, a valuable platform C5 compound, by engineered E. coli is low. Here, the authors achieve high titer and yield of glutarate production by pushing and pulling carbon flux in the native pathway and increasing intermediate influx using newly identified transporters.Wenna LiLin MaXiaolin ShenJia WangQi FengLexuan LiuGuojun ZhengYajun YanXinxiao SunQipeng YuanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenna Li Lin Ma Xiaolin Shen Jia Wang Qi Feng Lexuan Liu Guojun Zheng Yajun Yan Xinxiao Sun Qipeng Yuan Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production
description	The efficiency of producing glutarate, a valuable platform C5 compound, by engineered E. coli is low. Here, the authors achieve high titer and yield of glutarate production by pushing and pulling carbon flux in the native pathway and increasing intermediate influx using newly identified transporters.
format	article
author	Wenna Li Lin Ma Xiaolin Shen Jia Wang Qi Feng Lexuan Liu Guojun Zheng Yajun Yan Xinxiao Sun Qipeng Yuan
author_facet	Wenna Li Lin Ma Xiaolin Shen Jia Wang Qi Feng Lexuan Liu Guojun Zheng Yajun Yan Xinxiao Sun Qipeng Yuan
author_sort	Wenna Li
title	Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production
title_short	Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production
title_full	Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production
title_fullStr	Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production
title_full_unstemmed	Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production
title_sort	targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c821ea95ffe547eca9ec46dce1692df0
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Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production

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