Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production

The efficiency of producing glutarate, a valuable platform C5 compound, by engineered E. coli is low. Here, the authors achieve high titer and yield of glutarate production by pushing and pulling carbon flux in the native pathway and increasing intermediate influx using newly identified transporters...

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Autores principales: Wenna Li, Lin Ma, Xiaolin Shen, Jia Wang, Qi Feng, Lexuan Liu, Guojun Zheng, Yajun Yan, Xinxiao Sun, Qipeng Yuan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/c821ea95ffe547eca9ec46dce1692df0
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