Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells

Abstract There is a compelling need for the development of new sensory and neural prosthetic devices which are capable of more precise point stimulation. Current prosthetic devices suffer from the limitation of low spatial resolution due to the non-specific stimulation characteristics of electrical...

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Autores principales:	Parveen Bazard, Robert D. Frisina, Joseph P. Walton, Venkat R. Bhethanabotla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c82512d0dadf4cc7a84ca2147062d172
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spelling	oai:doaj.org-article:c82512d0dadf4cc7a84ca2147062d1722021-12-02T12:32:43ZNanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells10.1038/s41598-017-08141-42045-2322https://doaj.org/article/c82512d0dadf4cc7a84ca2147062d1722017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08141-4https://doaj.org/toc/2045-2322Abstract There is a compelling need for the development of new sensory and neural prosthetic devices which are capable of more precise point stimulation. Current prosthetic devices suffer from the limitation of low spatial resolution due to the non-specific stimulation characteristics of electrical stimulation, i.e., the spread of electric fields generated. We present a visible light stimulation method for modulating the firing patterns of electrically-excitable cells using surface plasmon resonance phenomena. In in-vitro studies using gold (Au) nanoparticle-coated nanoelectrodes, we show that this method (substrate coated with nanoparticles) has the potential for incorporating this new technology into neural stimulation prosthetics, such as cochlear implants for the deaf, with very high spatial resolution. Au nanoparticles (NPs) were coated on micropipettes using aminosilane linkers; and these micropipettes were used for stimulating and inhibiting the action potential firing patterns of SH-SY5Y human neuroblastoma cells and neonatal cardiomyocytes. Our findings pave the way for development of biomedical implants and neural testing devices using nanoelectrodes capable of temporally and spatially precise excitation and inhibition of electrically-excitable cellular activity.Parveen BazardRobert D. FrisinaJoseph P. WaltonVenkat R. BhethanabotlaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Parveen Bazard Robert D. Frisina Joseph P. Walton Venkat R. Bhethanabotla Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells
description	Abstract There is a compelling need for the development of new sensory and neural prosthetic devices which are capable of more precise point stimulation. Current prosthetic devices suffer from the limitation of low spatial resolution due to the non-specific stimulation characteristics of electrical stimulation, i.e., the spread of electric fields generated. We present a visible light stimulation method for modulating the firing patterns of electrically-excitable cells using surface plasmon resonance phenomena. In in-vitro studies using gold (Au) nanoparticle-coated nanoelectrodes, we show that this method (substrate coated with nanoparticles) has the potential for incorporating this new technology into neural stimulation prosthetics, such as cochlear implants for the deaf, with very high spatial resolution. Au nanoparticles (NPs) were coated on micropipettes using aminosilane linkers; and these micropipettes were used for stimulating and inhibiting the action potential firing patterns of SH-SY5Y human neuroblastoma cells and neonatal cardiomyocytes. Our findings pave the way for development of biomedical implants and neural testing devices using nanoelectrodes capable of temporally and spatially precise excitation and inhibition of electrically-excitable cellular activity.
format	article
author	Parveen Bazard Robert D. Frisina Joseph P. Walton Venkat R. Bhethanabotla
author_facet	Parveen Bazard Robert D. Frisina Joseph P. Walton Venkat R. Bhethanabotla
author_sort	Parveen Bazard
title	Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells
title_short	Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells
title_full	Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells
title_fullStr	Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells
title_full_unstemmed	Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells
title_sort	nanoparticle-based plasmonic transduction for modulation of electrically excitable cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c82512d0dadf4cc7a84ca2147062d172
work_keys_str_mv	AT parveenbazard nanoparticlebasedplasmonictransductionformodulationofelectricallyexcitablecells AT robertdfrisina nanoparticlebasedplasmonictransductionformodulationofelectricallyexcitablecells AT josephpwalton nanoparticlebasedplasmonictransductionformodulationofelectricallyexcitablecells AT venkatrbhethanabotla nanoparticlebasedplasmonictransductionformodulationofelectricallyexcitablecells
_version_	1718394005195063296

Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells

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