Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART

Abstract This study aimed to assess whether basal hormonal levels can predict the levels of progesterone (P4) on the day of oocyte retrieval (OR) and examine the impact of P4 levels on the day of OR on the outcome of assisted reproduction. One hundred sixty-four patients that were enrolled in the as...

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Autores principales:	L. Tulic, I. Tulic, J. Bila, Lj Nikolic, J. Dotlic, M Lazarevic-Suntov, I. Kalezic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c828428a5ed847b382057395de38e18d
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spelling	oai:doaj.org-article:c828428a5ed847b382057395de38e18d2021-12-02T13:34:10ZCorrelation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART10.1038/s41598-020-79347-22045-2322https://doaj.org/article/c828428a5ed847b382057395de38e18d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79347-2https://doaj.org/toc/2045-2322Abstract This study aimed to assess whether basal hormonal levels can predict the levels of progesterone (P4) on the day of oocyte retrieval (OR) and examine the impact of P4 levels on the day of OR on the outcome of assisted reproduction. One hundred sixty-four patients that were enrolled in the assisted reproduction procedure were classified according to their P4 levels on the OR day (< 2 ng/ml vs. ≥ 2 ng/ml). Patients who had P4 levels < 2 ng/ml had significantly higher follicle stimulating hormone (FSH) levels and significantly lower anti-Mullerian hormone (AMH) levels. More than half of patients with P4 levels < 2 ng/ml on the OR day got pregnant and delivered healthy infants. There was a significant correlation between lower FSH values and higher P4 values at OR and between higher AMH values and higher P4 values on the day of OR. Regression analysis showed that high FSH levels are the most important factor that can reliably imply lower P4 levels on OR day. Our study confirmed that lower basal FSH levels can predict the levels of P4 on the OR day. Moreover, lower levels of P4 on the day of OR are associated with a positive outcome in assisted reproduction.L. TulicI. TulicJ. BilaLj NikolicJ. DotlicM Lazarevic-SuntovI. KalezicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q L. Tulic I. Tulic J. Bila Lj Nikolic J. Dotlic M Lazarevic-Suntov I. Kalezic Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART
description	Abstract This study aimed to assess whether basal hormonal levels can predict the levels of progesterone (P4) on the day of oocyte retrieval (OR) and examine the impact of P4 levels on the day of OR on the outcome of assisted reproduction. One hundred sixty-four patients that were enrolled in the assisted reproduction procedure were classified according to their P4 levels on the OR day (< 2 ng/ml vs. ≥ 2 ng/ml). Patients who had P4 levels < 2 ng/ml had significantly higher follicle stimulating hormone (FSH) levels and significantly lower anti-Mullerian hormone (AMH) levels. More than half of patients with P4 levels < 2 ng/ml on the OR day got pregnant and delivered healthy infants. There was a significant correlation between lower FSH values and higher P4 values at OR and between higher AMH values and higher P4 values on the day of OR. Regression analysis showed that high FSH levels are the most important factor that can reliably imply lower P4 levels on OR day. Our study confirmed that lower basal FSH levels can predict the levels of P4 on the OR day. Moreover, lower levels of P4 on the day of OR are associated with a positive outcome in assisted reproduction.
format	article
author	L. Tulic I. Tulic J. Bila Lj Nikolic J. Dotlic M Lazarevic-Suntov I. Kalezic
author_facet	L. Tulic I. Tulic J. Bila Lj Nikolic J. Dotlic M Lazarevic-Suntov I. Kalezic
author_sort	L. Tulic
title	Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART
title_short	Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART
title_full	Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART
title_fullStr	Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART
title_full_unstemmed	Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART
title_sort	correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of art
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c828428a5ed847b382057395de38e18d
work_keys_str_mv	AT ltulic correlationofprogesteronelevelsonthedayofoocyteretrievalwithbasalhormonalstatusandtheoutcomeofart AT itulic correlationofprogesteronelevelsonthedayofoocyteretrievalwithbasalhormonalstatusandtheoutcomeofart AT jbila correlationofprogesteronelevelsonthedayofoocyteretrievalwithbasalhormonalstatusandtheoutcomeofart AT ljnikolic correlationofprogesteronelevelsonthedayofoocyteretrievalwithbasalhormonalstatusandtheoutcomeofart AT jdotlic correlationofprogesteronelevelsonthedayofoocyteretrievalwithbasalhormonalstatusandtheoutcomeofart AT mlazarevicsuntov correlationofprogesteronelevelsonthedayofoocyteretrievalwithbasalhormonalstatusandtheoutcomeofart AT ikalezic correlationofprogesteronelevelsonthedayofoocyteretrievalwithbasalhormonalstatusandtheoutcomeofart
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Correlation of progesterone levels on the day of oocyte retrieval with basal hormonal status and the outcome of ART

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