Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy.

<h4>Aim</h4>A recent meta-analysis of genome-wide linkage studies (GWLS) has identified multiple genetic regions suggestive of linkage with DN harboring hundreds of genes. Moving this number of genetic loci forward into biological insight is truly the next step. Here, we approach this ch...

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Autores principales:	Maria Tziastoudi, Aspasia Tsezou, Ioannis Stefanidis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c82855354eee4c99bfd31d1418ed43d4
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spelling	oai:doaj.org-article:c82855354eee4c99bfd31d1418ed43d42021-12-02T20:19:36ZCadherin and Wnt signaling pathways as key regulators in diabetic nephropathy.1932-620310.1371/journal.pone.0255728https://doaj.org/article/c82855354eee4c99bfd31d1418ed43d42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255728https://doaj.org/toc/1932-6203<h4>Aim</h4>A recent meta-analysis of genome-wide linkage studies (GWLS) has identified multiple genetic regions suggestive of linkage with DN harboring hundreds of genes. Moving this number of genetic loci forward into biological insight is truly the next step. Here, we approach this challenge with a gene ontology (GO) analysis in order to yield biological and functional role to the genes, an over-representation test to find which GO terms are enriched in the gene list, pathway analysis, as well as protein network analysis.<h4>Method</h4>GO analysis was performed using protein analysis through evolutionary relationships (PANTHER) version 14.0 software and P-values less than 0.05 were considered statistically significant. GO analysis was followed by over-representation test for the identification of enriched terms. Statistical significance was calculated by Fisher's exact test and adjusted using the false discovery rate (FDR) for correction of multiple tests. Cytoscape with the relevant plugins was used for the construction of the protein network and clustering analysis.<h4>Results</h4>The GO analysis assign multiple GO terms to the genes regarding the molecular function, the biological process and the cellular component, protein class and pathway analysis. The findings of the over-representation test highlight the contribution of cell adhesion regarding the biological process, integral components of plasma membrane regarding the cellular component, chemokines and cytokines with regard to protein class, while the pathway analysis emphasizes the contribution of Wnt and cadherin signaling pathways.<h4>Conclusions</h4>Our results suggest that a core feature of the pathogenesis of DN may be a disturbance in Wnt and cadherin signaling pathways, whereas the contribution of chemokines and cytokines need to be studied in additional studies.Maria TziastoudiAspasia TsezouIoannis StefanidisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255728 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Tziastoudi Aspasia Tsezou Ioannis Stefanidis Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy.
description	<h4>Aim</h4>A recent meta-analysis of genome-wide linkage studies (GWLS) has identified multiple genetic regions suggestive of linkage with DN harboring hundreds of genes. Moving this number of genetic loci forward into biological insight is truly the next step. Here, we approach this challenge with a gene ontology (GO) analysis in order to yield biological and functional role to the genes, an over-representation test to find which GO terms are enriched in the gene list, pathway analysis, as well as protein network analysis.<h4>Method</h4>GO analysis was performed using protein analysis through evolutionary relationships (PANTHER) version 14.0 software and P-values less than 0.05 were considered statistically significant. GO analysis was followed by over-representation test for the identification of enriched terms. Statistical significance was calculated by Fisher's exact test and adjusted using the false discovery rate (FDR) for correction of multiple tests. Cytoscape with the relevant plugins was used for the construction of the protein network and clustering analysis.<h4>Results</h4>The GO analysis assign multiple GO terms to the genes regarding the molecular function, the biological process and the cellular component, protein class and pathway analysis. The findings of the over-representation test highlight the contribution of cell adhesion regarding the biological process, integral components of plasma membrane regarding the cellular component, chemokines and cytokines with regard to protein class, while the pathway analysis emphasizes the contribution of Wnt and cadherin signaling pathways.<h4>Conclusions</h4>Our results suggest that a core feature of the pathogenesis of DN may be a disturbance in Wnt and cadherin signaling pathways, whereas the contribution of chemokines and cytokines need to be studied in additional studies.
format	article
author	Maria Tziastoudi Aspasia Tsezou Ioannis Stefanidis
author_facet	Maria Tziastoudi Aspasia Tsezou Ioannis Stefanidis
author_sort	Maria Tziastoudi
title	Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy.
title_short	Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy.
title_full	Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy.
title_fullStr	Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy.
title_full_unstemmed	Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy.
title_sort	cadherin and wnt signaling pathways as key regulators in diabetic nephropathy.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c82855354eee4c99bfd31d1418ed43d4
work_keys_str_mv	AT mariatziastoudi cadherinandwntsignalingpathwaysaskeyregulatorsindiabeticnephropathy AT aspasiatsezou cadherinandwntsignalingpathwaysaskeyregulatorsindiabeticnephropathy AT ioannisstefanidis cadherinandwntsignalingpathwaysaskeyregulatorsindiabeticnephropathy
_version_	1718374191350153216

Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy.

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