Ventral tegmental area astrocytes orchestrate avoidance and approach behavior

Ventral tegmental area astrocytes orchestrate avoidance and approach behavior

Astrocytes can dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT-1. Here, the authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GL...

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Bibliographic Details
Main Authors: J. A. Gomez, J. M. Perkins, G. M. Beaudoin, N. B. Cook, S. A. Quraishi, E. A. Szoeke, K. Thangamani, C. W. Tschumi, M. J. Wanat, A. M. Maroof, M. J. Beckstead, P. A. Rosenberg, C. A. Paladini
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
Q
Online Access:https://doaj.org/article/c82d0bc9e19e4ae49f59ed53ded7fe3d
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Summary:Astrocytes can dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT-1. Here, the authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GLT-1.

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