Ventral tegmental area astrocytes orchestrate avoidance and approach behavior

Ventral tegmental area astrocytes orchestrate avoidance and approach behavior

Astrocytes can dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT-1. Here, the authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GL...

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Detalles Bibliográficos
Autores principales: J. A. Gomez, J. M. Perkins, G. M. Beaudoin, N. B. Cook, S. A. Quraishi, E. A. Szoeke, K. Thangamani, C. W. Tschumi, M. J. Wanat, A. M. Maroof, M. J. Beckstead, P. A. Rosenberg, C. A. Paladini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/c82d0bc9e19e4ae49f59ed53ded7fe3d
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Sumario:Astrocytes can dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT-1. Here, the authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GLT-1.

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