Ventral tegmental area astrocytes orchestrate avoidance and approach behavior

Astrocytes can dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT-1. Here, the authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GL...

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Autores principales:	J. A. Gomez, J. M. Perkins, G. M. Beaudoin, N. B. Cook, S. A. Quraishi, E. A. Szoeke, K. Thangamani, C. W. Tschumi, M. J. Wanat, A. M. Maroof, M. J. Beckstead, P. A. Rosenberg, C. A. Paladini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c82d0bc9e19e4ae49f59ed53ded7fe3d
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spelling	oai:doaj.org-article:c82d0bc9e19e4ae49f59ed53ded7fe3d2021-12-02T14:38:58ZVentral tegmental area astrocytes orchestrate avoidance and approach behavior10.1038/s41467-019-09131-y2041-1723https://doaj.org/article/c82d0bc9e19e4ae49f59ed53ded7fe3d2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09131-yhttps://doaj.org/toc/2041-1723Astrocytes can dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT-1. Here, the authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GLT-1.J. A. GomezJ. M. PerkinsG. M. BeaudoinN. B. CookS. A. QuraishiE. A. SzoekeK. ThangamaniC. W. TschumiM. J. WanatA. M. MaroofM. J. BecksteadP. A. RosenbergC. A. PaladiniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. A. Gomez J. M. Perkins G. M. Beaudoin N. B. Cook S. A. Quraishi E. A. Szoeke K. Thangamani C. W. Tschumi M. J. Wanat A. M. Maroof M. J. Beckstead P. A. Rosenberg C. A. Paladini Ventral tegmental area astrocytes orchestrate avoidance and approach behavior
description	Astrocytes can dynamically control glutamate availability at specific active synapses through the glutamate transporter, GLT-1. Here, the authors show that astrocytes in the VTA selectively facilitate excitation of VTA GABAergic neurons to inhibit dopamine neurons and drive avoidance behavior via GLT-1.
format	article
author	J. A. Gomez J. M. Perkins G. M. Beaudoin N. B. Cook S. A. Quraishi E. A. Szoeke K. Thangamani C. W. Tschumi M. J. Wanat A. M. Maroof M. J. Beckstead P. A. Rosenberg C. A. Paladini
author_facet	J. A. Gomez J. M. Perkins G. M. Beaudoin N. B. Cook S. A. Quraishi E. A. Szoeke K. Thangamani C. W. Tschumi M. J. Wanat A. M. Maroof M. J. Beckstead P. A. Rosenberg C. A. Paladini
author_sort	J. A. Gomez
title	Ventral tegmental area astrocytes orchestrate avoidance and approach behavior
title_short	Ventral tegmental area astrocytes orchestrate avoidance and approach behavior
title_full	Ventral tegmental area astrocytes orchestrate avoidance and approach behavior
title_fullStr	Ventral tegmental area astrocytes orchestrate avoidance and approach behavior
title_full_unstemmed	Ventral tegmental area astrocytes orchestrate avoidance and approach behavior
title_sort	ventral tegmental area astrocytes orchestrate avoidance and approach behavior
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c82d0bc9e19e4ae49f59ed53ded7fe3d
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Ventral tegmental area astrocytes orchestrate avoidance and approach behavior

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