The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications

The well-known symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are chronic pain, cognitive dysfunction, post-exertional malaise and severe fatigue. Another class of symptoms commonly reported in the context of ME/CFS are gastrointestinal (GI) problems. These may occur due to...

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Autores principales:	Angelica Varesi, Undine-Sophie Deumer, Sanjana Ananth, Giovanni Ricevuti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ME/CFS dysbiosis therapy diagnosis intestinal permeability metabolic endotoxemia Medicine R
Acceso en línea:	https://doaj.org/article/c8301697e98e470fa4587f4149905d0d
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spelling	oai:doaj.org-article:c8301697e98e470fa4587f4149905d0d2021-11-11T17:42:10ZThe Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications10.3390/jcm102150772077-0383https://doaj.org/article/c8301697e98e470fa4587f4149905d0d2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5077https://doaj.org/toc/2077-0383The well-known symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are chronic pain, cognitive dysfunction, post-exertional malaise and severe fatigue. Another class of symptoms commonly reported in the context of ME/CFS are gastrointestinal (GI) problems. These may occur due to comorbidities such as Crohn’s disease or irritable bowel syndrome (IBS), or as a symptom of ME/CFS itself due to an interruption of the complex interplay between the gut microbiota (GM) and the host GI tract. An altered composition and overall decrease in diversity of GM has been observed in ME/CFS cases compared to controls. In this review, we reflect on genetics, infections, and other influences that may factor into the alterations seen in the GM of ME/CFS individuals, we discuss consequences arising from these changes, and we contemplate the therapeutic potential of treating the gut to alleviate ME/CFS symptoms holistically.Angelica VaresiUndine-Sophie DeumerSanjana AnanthGiovanni RicevutiMDPI AGarticleME/CFSdysbiosistherapydiagnosisintestinal permeabilitymetabolic endotoxemiaMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5077, p 5077 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ME/CFS dysbiosis therapy diagnosis intestinal permeability metabolic endotoxemia Medicine R
spellingShingle	ME/CFS dysbiosis therapy diagnosis intestinal permeability metabolic endotoxemia Medicine R Angelica Varesi Undine-Sophie Deumer Sanjana Ananth Giovanni Ricevuti The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications
description	The well-known symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are chronic pain, cognitive dysfunction, post-exertional malaise and severe fatigue. Another class of symptoms commonly reported in the context of ME/CFS are gastrointestinal (GI) problems. These may occur due to comorbidities such as Crohn’s disease or irritable bowel syndrome (IBS), or as a symptom of ME/CFS itself due to an interruption of the complex interplay between the gut microbiota (GM) and the host GI tract. An altered composition and overall decrease in diversity of GM has been observed in ME/CFS cases compared to controls. In this review, we reflect on genetics, infections, and other influences that may factor into the alterations seen in the GM of ME/CFS individuals, we discuss consequences arising from these changes, and we contemplate the therapeutic potential of treating the gut to alleviate ME/CFS symptoms holistically.
format	article
author	Angelica Varesi Undine-Sophie Deumer Sanjana Ananth Giovanni Ricevuti
author_facet	Angelica Varesi Undine-Sophie Deumer Sanjana Ananth Giovanni Ricevuti
author_sort	Angelica Varesi
title	The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications
title_short	The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications
title_full	The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications
title_fullStr	The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications
title_full_unstemmed	The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications
title_sort	emerging role of gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs): current evidence and potential therapeutic applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c8301697e98e470fa4587f4149905d0d
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The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications

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