An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells

Inefficient delivery of proteins into mammalian cells limits their use in research and therapy. Here, the authors discover that ProTα, a small, intrinsically disordered human protein can facilitate efficient cationic lipid-mediated protein delivery of genome editing proteins into mammalian cells.

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Autores principales:	Y. Bill Kim, Kevin T. Zhao, David B. Thompson, David R. Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c835099de4814592bcbecee8ffae3aee
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spelling	oai:doaj.org-article:c835099de4814592bcbecee8ffae3aee2021-12-02T15:35:14ZAn anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells10.1038/s41467-019-10828-32041-1723https://doaj.org/article/c835099de4814592bcbecee8ffae3aee2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10828-3https://doaj.org/toc/2041-1723Inefficient delivery of proteins into mammalian cells limits their use in research and therapy. Here, the authors discover that ProTα, a small, intrinsically disordered human protein can facilitate efficient cationic lipid-mediated protein delivery of genome editing proteins into mammalian cells.Y. Bill KimKevin T. ZhaoDavid B. ThompsonDavid R. LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Y. Bill Kim Kevin T. Zhao David B. Thompson David R. Liu An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells
description	Inefficient delivery of proteins into mammalian cells limits their use in research and therapy. Here, the authors discover that ProTα, a small, intrinsically disordered human protein can facilitate efficient cationic lipid-mediated protein delivery of genome editing proteins into mammalian cells.
format	article
author	Y. Bill Kim Kevin T. Zhao David B. Thompson David R. Liu
author_facet	Y. Bill Kim Kevin T. Zhao David B. Thompson David R. Liu
author_sort	Y. Bill Kim
title	An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells
title_short	An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells
title_full	An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells
title_fullStr	An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells
title_full_unstemmed	An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells
title_sort	anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c835099de4814592bcbecee8ffae3aee
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An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells

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